- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 346761, 7 pages
Advancement in the Development of Models for Hepatitis C Research
1Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, FL 32610, USA
2Center for Orphan Autoimmune Disorders, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
3Department of Infectious Diseases and Pathology, University of Florida, 2015 SW 16th Avenue, Gainesville, Florida 32608-00881, USA
Received 18 January 2012; Accepted 2 April 2012
Academic Editor: Andrea Vecchione
Copyright © 2012 Wendy C. Carcamo and Cuong Q. Nguyen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. H. Hoofnagle, “Course and outcome of hepatitis C,” Hepatology, vol. 36, no. 5, supplement 1, pp. S21–S29, 2002.
- “National Institutes of Health Consensus Development Conference Statement: management of hepatitis C 2002 (June 10–12, 2002),” Gastroenterology, vol. 123, no. 6, pp. 2082–2099, 2002.
- H. J. Alter and L. B. Seeff, “Recovery, persistence, and sequelae in hepatitis C virus infection: a perspective on long-term outcome,” Seminars in Liver Disease, vol. 20, no. 1, pp. 17–35, 2000.
- M. Charlton, “Hepatitis C infection in liver transplantation,” American Journal of Transplantation, vol. 1, no. 3, pp. 197–203, 2001.
- L. B. Seeff, “Natural history of hepatitis C,” Hepatology, vol. 26, no. 3, supplement 1, pp. 21S–28S, 1997.
- E. Foy, K. Li, C. Wang et al., “Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease,” Science, vol. 300, no. 5622, pp. 1145–1148, 2003.
- M. W. Fried, M. L. Shiffman, K. Rajender Reddy et al., “Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection,” New England Journal of Medicine, vol. 347, no. 13, pp. 975–982, 2002.
- S. J. Hadziyannis, H. Sette, T. R. Morgan et al., “Peginterferon-α2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose,” Annals of Internal Medicine, vol. 140, no. 5, pp. 346–I67, 2004.
- M. P. Manns, J. G. McHutchison, S. C. Gordon et al., “Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial,” Lancet, vol. 358, no. 9286, pp. 958–965, 2001.
- A. Kau, J. Vermehren, and C. Sarrazin, “Treatment predictors of a sustained virologic response in hepatitis B and C,” Journal of Hepatology, vol. 49, no. 4, pp. 634–651, 2008.
- K. R. Smith, V. Suppiah, K. O'Connor et al., “Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort,” Genome Medicine, vol. 3, no. 8, p. 57, 2011.
- P. Simmonds, J. Bukh, C. Combet et al., “Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes,” Hepatology, vol. 42, no. 4, pp. 962–973, 2005.
- Q. L. Choo, G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley, and M. Houghton, “Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome,” Science, vol. 244, no. 4902, pp. 359–362, 1989.
- G. M. Lauer and B. D. Walker, “Hepatitis C virus infection,” New England Journal of Medicine, vol. 345, no. 1, pp. 41–52, 2001.
- L. B. Dustin and C. M. Rice, “Flying under the radar: the immunobiology of hepatitis C,” Annual Review of Immunology, vol. 25, pp. 71–99, 2007.
- S. Rosenberg, “Recent advances in the molecular biology of Hepatitis C virus,” Journal of Molecular Biology, vol. 313, no. 3, pp. 451–464, 2001.
- A. O. De Beeck and J. Dubuisson, “Topology of hepatitis C virus envelope glycoproteins,” Reviews in Medical Virology, vol. 13, no. 4, pp. 233–241, 2003.
- N. Kato, “Genome of human hepatitis C virus (HCV): gene organization, sequence diversity, and variation,” Microbial and Comparative Genomics, vol. 5, no. 3, pp. 129–151, 2000.
- K. I. Ohba, M. Mizokami, J. Y. N. Lau, E. Orito, K. Ikeo, and T. Gojobori, “Evolutionary relationship of hepatitis C, pesti-, flavi-, plantviruses, and newly discovered GB hepatitis agents,” FEBS Letters, vol. 378, no. 3, pp. 232–234, 1996.
- F. Penin, J. Dubuisson, F. A. Rey, D. Moradpour, and J. M. Pawlotsky, “Structural biology of hepatitis C virus,” Hepatology, vol. 39, no. 1, pp. 5–19, 2004.
- V. Lohmann, J. O. Koch, and R. Bartenschlager, “Processing pathways of the hepatitis C virus proteins,” Journal of Hepatology, Supplement, vol. 24, supplement 2, pp. 11–19, 1996.
- R. Bartenschlager and V. Lohmann, “Replication of hepatitis C virus,” Journal of General Virology, vol. 81, no. 7, pp. 1631–1648, 2000.
- M. J. Evans, T. Von Hahn, D. M. Tscherne et al., “Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry,” Nature, vol. 446, no. 7137, pp. 801–805, 2007.
- B. Bartosch and F. L. Cosset, “Cell entry of hepatitis C virus,” Virology, vol. 348, no. 1, pp. 1–12, 2006.
- L. Cocquerel, C. Voisset, and J. Dubuisson, “Hepatitis C virus entry: potential receptors and their biological functions,” Journal of General Virology, vol. 87, no. 5, pp. 1075–1084, 2006.
- I. Kohaar, A. Ploss, E. Korol et al., “Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry,” Journal of Virology, vol. 84, no. 14, pp. 6987–6994, 2010.
- K. Ray, “Hepatitis: NPC1L1 identified as a novel HCV entry factor,” Nature Reviews Gastroenterology and Hepatology, vol. 9, no. 3, 124.
- B. Sainz Jr, N. Barretto, D. N. Martin et al., “Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor,” Nature Medicine, vol. 18, no. 2, pp. 281–285, 2012.
- B. D. Lindenbach and C. M. Rice, “Unravelling hepatitis C virus replication from genome to function,” Nature, vol. 436, no. 7053, pp. 933–938, 2005.
- N. Pavio and M. M. C. Lai, “The hepatitis C virus persistence: how to evade the immune system?” Journal of Biosciences, vol. 28, no. 3, pp. 287–304, 2003.
- R. Bartenschlager, “Hepatitis C virus replicons: potential role for drug development,” Nature Reviews Drug Discovery, vol. 1, no. 11, pp. 911–916, 2002.
- S. Iacovacci, A. Manzin, S. Barca et al., “Molecular characterization and dynamics of hepatitis C virus replication in human fetal hepatocytes infected in vitro,” Hepatology, vol. 26, no. 5, pp. 1328–1337, 1997.
- S. Iacovacci, M. Sargiacomo, I. Parolini, A. Ponzetto, C. Peschle, and G. Carloni, “Replication and multiplication of hepatitis C virus genome in human foetal liver cells,” Research in Virology, vol. 144, no. 4, pp. 275–279, 1993.
- R. E. Lanford, C. Sureau, J. R. Jacob, R. White, and T. R. Fuerst, “Demonstration of in vitro infection of chimpanzee hepatocytes with hepatitis C virus using strand-specific RT/PCR,” Virology, vol. 202, no. 2, pp. 606–614, 1994.
- S. Rumin, P. Berthillon, E. Tanaka et al., “Dynamic analysis of hepatitis C virus replication and quasispecies selection in long-term cultures of adult human hepatocytes infected in vitro,” Journal of General Virology, vol. 80, no. 11, pp. 3007–3018, 1999.
- B. Cribier, C. Schmitt, A. Bingen, A. Kirn, and F. Keller, “In vitro infection of peripheral blood mononuclear cells by hepatitis C virus,” Journal of General Virology, vol. 76, no. 10, pp. 2485–2491, 1995.
- M. Ikeda, K. Sugiyama, T. Mizutani et al., “Human hepatocyte clonal cell lines that support persistent replication of hepatitis C virus,” Virus Research, vol. 56, no. 2, pp. 157–167, 1998.
- N. Kato, M. Ikeda, T. Mizutani et al., “Replication of hepatitis C virus in cultured non-neoplastic human hepatocytes,” Japanese Journal of Cancer Research, vol. 87, no. 8, pp. 787–792, 1996.
- T. Mizutani, N. Kato, M. Ikeda, K. Sugiyama, and K. Shimotohno, “Long-term human T-cell culture system supporting hepatitis C virus replication,” Biochemical and Biophysical Research Communications, vol. 227, no. 3, pp. 822–826, 1996.
- N. Nakajima, M. Hijikata, H. Yoshikura, and Y. K. Shimizu, “Characterization of long-term cultures of hepatitis C virus,” Journal of Virology, vol. 70, no. 5, pp. 3325–3329, 1996.
- Y. K. Shimizu, H. Igarashi, T. Kiyohara et al., “Infection of a chimpanzee with hepatitis C virus grown in cell culture,” Journal of General Virology, vol. 79, no. 6, pp. 1383–1386, 1998.
- B. J. Yoo, M. J. Selby, J. Choe et al., “Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long- term culture persistently infected with HCV,” Journal of Virology, vol. 69, no. 1, pp. 32–38, 1995.
- S. Dash, A. B. Halim, H. Tsuji, N. Hiramatsu, and M. A. Gerber, “Transfection of HepG2 cells with infectious hepatitis C virus genome,” American Journal of Pathology, vol. 151, no. 2, pp. 363–373, 1997.
- M. Yanagi, M. S. Claire, S. U. Emerson, R. H. Purcell, and J. Bukh, “In vivo analysis of the 3′ untranslated region of the hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 5, pp. 2291–2295, 1999.
- A. A. Kolykhalov, K. Mihalik, S. M. Feinstone, and C. M. Rice, “Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo,” Journal of Virology, vol. 74, no. 4, pp. 2046–2051, 2000.
- V. Lohmann, F. Körner, J. O. Koch, U. Herian, L. Theilmann, and R. Bartenschlager, “Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line,” Science, vol. 285, no. 5424, pp. 110–113, 1999.
- S. E. Behrens, C. W. Grassmann, H. J. Thiel, G. Meyers, and N. Tautz, “Characterization of an autonomous subgenomic pestivirus RNA replicon,” Journal of Virology, vol. 72, no. 3, pp. 2364–2372, 1998.
- P. Liljestrom and H. Garoff, “A new generation of animal cell expression vectors based on the Semliki Forest virus replicon,” Bio/Technology, vol. 9, no. 12, pp. 1356–1361, 1991.
- A. A. Khromykh and E. G. Westaway, “Subgenomic replicons of the flavivirus Kunjin: construction and applications,” Journal of Virology, vol. 71, no. 2, pp. 1497–1505, 1997.
- T. Pietschmann, V. Lohmann, G. Rutter, K. Kurpanek, and R. Bartenschlager, “Characterization of cell lines carrying self-replicating hepatitis C virus RNAs,” Journal of Virology, vol. 75, no. 3, pp. 1252–1264, 2001.
- N. Krieger, V. Lohmann, and R. Bartenschlager, “Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations,” Journal of Virology, vol. 75, no. 10, pp. 4614–4624, 2001.
- V. Lohmann, F. Körner, A. Dobierzewska, and R. Bartenschlager, “Mutations in hepatitis C virus RNAs conferring cell culture adaptation,” Journal of Virology, vol. 75, no. 3, pp. 1437–1449, 2001.
- T. Kato, T. Date, M. Miyamoto et al., “Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon,” Gastroenterology, vol. 125, no. 6, pp. 1808–1817, 2003.
- T. Wakita, T. Pietschmann, T. Kato et al., “Production of infectious hepatitis C virus in tissue culture from a cloned viral genome,” Nature Medicine, vol. 11, no. 7, pp. 791–796, 2005.
- B. D. Lindenbach, M. J. Evans, A. J. Syder et al., “Virology: complete replication of hepatitis C virus in cell culture,” Science, vol. 309, no. 5734, pp. 623–626, 2005.
- B. D. Lindenbach, P. Meuleman, A. Ploss et al., “Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 10, pp. 3805–3809, 2006.
- N. Kato, K. Mori, K. I. Abe et al., “Efficient replication systems for hepatitis C virus using a new human hepatoma cell line,” Virus Research, vol. 146, no. 1-2, pp. 41–50, 2009.
- H. Kambara, T. Fukuhara, M. Shiokawa et al., “Establishment of a novel permissive cell line for the propagation of hepatitis C virus by expression of microRNA miR122,” Journal of Virology, vol. 86, no. 3, pp. 1382–1393, 2012.
- T. Shimakami, D. Yamane, R.K. Jangra et al., “Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 3, pp. 941–946, 2012.
- J. Bukh, “A critical role for the chimpanzee model in the study of hepatitis C,” Hepatology, vol. 39, no. 6, pp. 1469–1475, 2004.
- P. Farci, H. J. Alter, S. Govindarajan et al., “Lack of protective immunity against reinfection with hepatitis C virus,” Science, vol. 258, no. 5079, pp. 135–140, 1992.
- A. M. Prince, B. Brotman, T. Huima, D. Pascual, M. Jaffery, and G. Inchauspe, “Immunity in hepatitis C infection,” Journal of Infectious Diseases, vol. 165, no. 3, pp. 438–443, 1992.
- R. Q. Yan, J. J. Su, D. R. Huang, Y. C. Gan, C. Yang, and G. H. Huang, “Human hepatitis B virus and hepatocellular carcinoma II. Experimental induction of hepatocellular carcinoma in tree shrews exposed to hepatitis B virus and aflatoxin B1,” Journal of Cancer Research and Clinical Oncology, vol. 122, no. 5, pp. 289–295, 1996.
- E. Walter, R. Keist, B. Niederöst, I. Pult, and H. E. Blum, “Hepatitis B virus infection of tupaia hepatocytes in vitro and in vivo,” Hepatology, vol. 24, no. 1, pp. 1–5, 1996.
- Z. C. Xie, J. I. Riezu-Boj, J. J. Lasarte et al., “Transmission of hepatitis C virus infection to tree shrews,” Virology, vol. 244, no. 2, pp. 513–520, 1998.
- X. Zhao, Z. Y. Tang, B. Klumpp et al., “Primary hepatocytes of Tupaia belangeri as a potential model for hepatitis C virus infection,” Journal of Clinical Investigation, vol. 109, no. 2, pp. 221–232, 2002.
- D. F. Mercer, D. E. Schiller, J. F. Elliott et al., “Hepatitis C virus replication in mice with chimeric human livers,” Nature Medicine, vol. 7, no. 8, pp. 927–933, 2001.
- P. Meuleman and G. Leroux-Roels, “The human liver-uPA-SCID mouse: a model for the evaluation of antiviral compounds against HBV and HCV,” Antiviral Research, vol. 80, no. 3, pp. 231–238, 2008.
- T. Vanwolleghem, J. Bukh, P. Meuleman et al., “Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain,” Hepatology, vol. 47, no. 6, pp. 1846–1855, 2008.
- A. Ploss, M. J. Evans, V. A. Gaysinskaya et al., “Human occludin is a hepatitis C virus entry factor required for infection of mouse cells,” Nature, vol. 457, no. 7231, pp. 882–886, 2009.
- M. Dorner, J. A. Horwitz, J. B. Robbins et al., “A genetically humanized mouse model for hepatitis C virus infection,” Nature, vol. 474, no. 7350, pp. 208–212, 2011.
- W. C. Carcamo, M. Satoh, H. Kasahara et al., “Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cells,” PLoS ONE, vol. 6, no. 12, Article ID e29690, 2011.
- G. Covini, W. C. Carcamo, E. Bredi, C. A. von Muhlen, M. Colombo, and E. K. Chan, “Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C,” Antiretroviral Therapy. In press.