Multiple Signaling Pathways Are Involved in the Interleukine-4 Regulated Expression of DC-SIGN in THP-1 Cell Line
Figure 5
The relative activity of complete DC-SIGN promoters and those without AP-1 or ETS-1 transcription factor binding factors. The activities of luciferase reporter vectors of different DC-SIGN promoters were detected in 293T cells (part a), Hacat cells (part b) and untreated, PMA or PMA+IL-4-treated THP-1 cells (part c). The abbreviation in the figures: AP-B, pGL-3/Basic/DC-SIGN without AP-1 transcription factor binding factor; AP-E, pGL-3/Enhancer/DC-SIGN without AP-1 transcription factor binding factor; ETS-B, pGL-3/Basic/DC-SIGN without ETS-1 transcription factor binding factor; ETS-E, pGL-3/Enhancer/DC-SIGN without ETS-1 transcription factor binding factor; B, pGL-3/Basic/DC-SIG; E, pGL-3/Enhancer/DC-SIGN; Negative, the internal control plasmid pRL-TK. *means ; **means .
