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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 359879, 9 pages
Biomarkers of Adverse Response to Mercury: Histopathology versus Thioredoxin Reductase Activity
1Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon,
Avenue Professor Gama Pinto, 1649-003 Lisbon, Portugal
2Marine Environment and Biodiversity Unit, Institute for Sea and Atmospheric Research (IPIMAR/IPMA), Avenue Brasília, 1440-006 Lisbon, Portugal
3Aquaculture Unit, Institute for Sea and Atmospheric Research (IPIMAR/IPMA), Avenue Brasília, 1440-006 Lisbon, Portugal
4Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden
Received 20 April 2012; Accepted 25 May 2012
Academic Editor: João B.T. Rocha
Copyright © 2012 Vasco Branco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- T. W. Clarkson and L. Magos, “The toxicology of mercury and its chemical compounds,” Critical Reviews in Toxicology, vol. 36, no. 8, pp. 609–662, 2006.
- C. W. J. Chang, R. M. Nakamura, and C. C. Brooks, “Effect of varied dietary levels and forms of mercury on swine,” Journal of Animal Science, vol. 45, no. 2, pp. 279–285, 1977.
- C. Liao, J. Fu, J. Shi, Q. Zhou, C. Yuan, and G. Jiang, “Methylmercury accumulation, histopathology effects, and cholinesterase activity alterations in medaka (Oryzias latipes) following sublethal exposure to methylmercury chloride,” Environmental Toxicology and Pharmacology, vol. 22, no. 2, pp. 225–233, 2006.
- V. Branco, J. Canário, A. Holmgren, and C. Carvalho, “Inhibition of the thioredoxin system in the brain and liver of zebra-seabreams exposed to waterborne methylmercury,” Toxicology and Applied Pharmacology, vol. 251, no. 2, pp. 95–103, 2011.
- N. K. Mottet, M. E. Vahter, J. S. Charleston, and L. T. Friberg, Metabolism of Methylmercury in the Brain and Its Toxicological Significance, Marcel Dekker, New York, NY, USA, 1997.
- D. Yang, C. Yu-Wei, J. M. Gunn, and N. Belzile, “Selenium and mercury in organisms: interactions and mechanisms,” Environmental Reviews, vol. 16, pp. 71–92, 2008.
- J. Parizek, I. Ostadalova, J. Kalouskva, A. Babichy, and J. Benes, The Detoxifying Effects of Selenium. Interrelation Between Compounds of Selenium and Certain Metals, Marcel Dekker, New York, NY, USA, 1971.
- M. A. K. Khan and F. Wang, “Mercury-selenium compounds and their toxicological significance: toward a molecular understanding of the mercury-selenium antagonism,” Environmental Toxicology and Chemistry, vol. 28, no. 8, pp. 1567–1577, 2009.
- P. W. Wester and H. H. Canton, “Histopathological effects in Poecilia reticulata (guppy) exposed to methyl mercury chloride,” Toxicologic Pathology, vol. 20, no. 1, pp. 81–92, 1992.
- R. K. Zalups, “Molecular interactions with mercury in the kidney,” Pharmacological Reviews, vol. 52, no. 1, pp. 113–143, 2000.
- L. H. Lash, S. E. Hueni, D. A. Putt, and R. K. Zalups, “Role of organic anion and amino acid carriers in transport of inorganic mercury in rat renal basolateral membrane vesicles: influence of compensatory renal growth,” Toxicological Sciences, vol. 88, no. 2, pp. 630–644, 2005.
- T. Giovanoli-Jakubczak, M. R. Greenwood, J. C. Smith, and T. W. Clarkson, “Determination of total and inorganic mercury in hair by flameless atomic absorption, and of methylmercury by gas chromatography,” Clinical Chemistry, vol. 20, no. 2, pp. 222–229, 1974.
- H. Satoh, “Occupational and environmental toxicology of mercury and its compounds,” Industrial Health, vol. 38, no. 2, pp. 153–164, 2000.
- J. C. Gage, “Distribution and excretion of methyl and phenyl mercury salts,” British Journal of Industrial Medicine, vol. 21, no. 3, pp. 197–202, 1964.
- M. Berglund, B. Lind, K. A. Björnberg, B. Palm, Ö. Einarsson, and M. Vahter, “Inter-individual variations of human mercury exposure biomarkers: a cross-sectional assessment,” Environmental Health: A Global Access Science Source, vol. 4, article 20, 2005.
- J. C. Gage, “The distribution and excretion of inhaled mercury vapour,” British Journal of Industrial Medicine, vol. 18, no. 4, pp. 287–294, 1961.
- S. Bose-O'Reilly, K. M. McCarty, N. Steckling, and B. Lettmeier, “Mercury exposure and children's health,” Current Problems in Pediatric and Adolescent Health Care, vol. 40, no. 8, pp. 186–215, 2010.
- T. Iwata, M. Sakamoto, X. Feng et al., “Effects of mercury vapor exposure on neuromotor function in Chinese miners and smelters,” International Archives of Occupational and Environmental Health, vol. 80, no. 5, pp. 381–387, 2007.
- A. P. M. dos Santos, M. L. Mateus, C. M. L. Carvalho, and M. C. C. Batoréu, “Biomarkers of exposure and effect as indicators of the interference of selenomethionine on methylmercury toxicity,” Toxicology Letters, vol. 169, no. 2, pp. 121–128, 2007.
- J. S. Woods, Porphyrin Metabolism as Indicator of Metal Exposure and Toxicity, Springer, Berlin, Germany, 1995.
- J. S. Woods, M. D. Martin, B. G. Leroux et al., “Urinary porphyrin excretion in children with mercury amalgam treatment: findings from the Casa Pia children's dental amalgam trial,” Journal of Toxicology and Environmental Health A, vol. 72, no. 14, pp. 891–896, 2009.
- S. Oh and M. Lee, “Interaction between inorganic mercury and selenium on tissue sulfhydryl groups and glutathione-linked enzymes in rats,” Yonsei Medical Journal, vol. 22, no. 2, pp. 122–126, 1981.
- F. Livardjani, M. Ledig, P. Kopp, M. Dahlet, M. Leroy, and A. Jaeger, “Lung and blood superoxide dismutase activity in mercury vapor exposed rats: effect of N-acetylcysteine treatment,” Toxicology, vol. 66, no. 3, pp. 289–295, 1991.
- R. Perrin-Nadif, M. Dusch, C. Koch, P. Schmitt, and J. M. Mur, “Catalase and superoxide dismutase activities as biomarkers of oxidative stress in workers exposed to mercury vapors,” Journal of Toxicology and Environmental Health A, vol. 48, no. 2, pp. 107–119, 1996.
- T. Sarafian and M. A. Verity, “Oxidative mechanisms underlying methyl mercury neurotoxicity,” International Journal of Developmental Neuroscience, vol. 9, no. 2, pp. 147–153, 1991.
- B. O. Lund, D. M. Miller, and J. S. Woods, “Studies on Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria,” Biochemical Pharmacology, vol. 45, no. 10, pp. 2017–2024, 1993.
- M. G. Cherian and T. W. Clarkson, “Biochemical changes in rat kidney on exposure to elemental mercury vapor: effect on biosynthesis of metallothionein,” Chemico-Biological Interactions, vol. 12, no. 2, pp. 109–120, 1976.
- C. M. L. Carvalho, E. Chew, S. I. Hashemy, J. Lu, and A. Holmgren, “Inhibition of the human thioredoxin system: a molecular mechanism of mercury toxicity,” The Journal of Biological Chemistry, vol. 283, no. 18, pp. 11913–11923, 2008.
- O. Wada, N. Yamaguchi, T. Ono, M. Nagahashi, and T. Morimura, “Inhibitory effect of mercury on kidney glutathione peroxidase and its prevention by selenium,” Environmental Research, vol. 12, no. 1, pp. 75–80, 1976.
- C. Watanabe, K. Yoshida, Y. Kasanuma, Y. Kun, and H. Satoh, “In utero methylmercury exposure differentially affects the activities of selenoenzymes in the fetal mouse brain,” Environmental Research, vol. 80, no. 3, pp. 208–214, 1999.
- C. Bulato, V. Bosello, F. Ursini, and M. Maiorino, “Effect of mercury on selenium utilization and selenoperoxidase activity in LNCaP cells,” Free Radical Biology and Medicine, vol. 42, no. 1, pp. 118–123, 2007.
- J. L. Franco, T. Posser, P. R. Dunkley et al., “Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase,” Free Radical Biology and Medicine, vol. 47, no. 4, pp. 449–457, 2009.
- C. M. L. Carvalho, J. Lu, X. Zhang, E. S. J. Arnér, and A. Holmgren, “Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning,” The FASEB Journal, vol. 25, no. 1, pp. 370–381, 2011.
- V. Branco, J. Canário, J. Lu, A. Holmgren, and C. Carvalho, “Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase,” Free Radical Biology and Medicine, vol. 52, no. 4, pp. 781–793, 2012.
- C. Wagner, J. H. Sudati, C. W. Nogueira, and J. B. Rocha, “In vivo and in vitro inhibition of mice thioredoxin reductase by methylmercury,” BioMetals, vol. 23, no. 6, pp. 1171–1177, 2010.
- C. H. Lillig and A. Holmgren, “Thioredoxin and related molecules—from biology to health and disease,” Antioxidants and Redox Signaling, vol. 9, no. 1, pp. 25–47, 2007.
- J. C. Wolf and M. J. Wolfe, “A brief overview of nonneoplastic hepatic toxicity in fish,” Toxicologic Pathology, vol. 33, no. 1, pp. 75–85, 2005.
- D. Bernet, H. Schmidt, W. Meier, P. Burkhardt-Holm, and T. Wahli, “Histopathology in fish: proposal for a protocol to assess aquatic pollution,” Journal of Fish Diseases, vol. 22, no. 1, pp. 25–34, 1999.
- R. D. Lillie and H. M. Fullmer, Histopathologic Technic and Practical Histochemistry, McGraw- Hill, New York, NY, USA, 1976.
- M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248–254, 1976.
- E. S. J. Arnér and A. Holmgren, Measurement of Thioredoxin and Thioredoxin Reductase, John Wiley & Sons, New York, NY, USA, 1999.
- B. Mannervik, Measurement of Glutathione Reductase Activity, John Wiley & Sons, New York, NY, USA, 1999.
- J. H. Zar, Biostatistical Analysis, Prentice Hall, New Jersey, NJ, USA, 1999.
- M. Mela, M. A. F. Randi, D. F. Ventura, C. E. V. Carvalho, E. Pelletier, and C. A. O. Oliveira, “Effects of dietary methylmercury on liver and kidney histology in the neotropical fish Hoplias malabaricus,” Ecotoxicology and Environmental Safety, vol. 68, no. 3, pp. 426–435, 2007.
- C. A. O. Ribeiro, L. Belger, E. Pelletier, and C. Rouleau, “Histopathological evidence of inorganic mercury and methyl mercury toxicity in the arctic charr (Salvelinus alpinus),” Environmental Research, vol. 90, no. 3, pp. 217–225, 2002.
- M. Conrad, “Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4,” Biochimica et Biophysica Acta, vol. 1790, no. 11, pp. 1575–1585, 2009.