Table 1: Values of the organ damage index* (ODI) calculated for the liver and kidney of zeabra-seabreams exposed to the different treatments. No lesions were observed in control fishes. MeHg: exposure to Methylmercury; HgII: exposure to Hg2+; MeHgSe: coexposure to MeHg and Se; HgSe: coexposure to Hg2+ and Se; MeHgRSe: exposure to MeHg followed by exposure to Se during depuration; HgRSe: exposure to Hg2+ followed by exposure to Se during depuration; Se: exposure to selenium.

Organ lesion (OL)PiMeHgHgIIMeHgSeHgSeMeHgRSeHgRSeSe
d28d42d28d42d28d42d28d42d42d42d28d42
𝑁 O L 𝑁 O L 𝑁 O L 𝑁 O L 𝑁 O L 𝑁 O L 𝑁 O L 𝑁 O L 𝑁 O L 𝑁 O L 𝑁 O L 𝑁 O L

LiverArchitectural pattern lost1434432403320
Vacuolar degeneration1314120123320
Hydropic degeneration1423112110300
Hypertrophy of hepatocytes2231440410000
Extensive focal necrosis3032402130200
Focal necrosis2300012203100
Parenchymal congestion1012010300000
Pigment deposition1002000000000

ODI2122232617142414121740

KidneyVacuolar degeneration1101211011200
Hydropic degeneration1321013030200
Pigment deposition1311102011000
Parenchymal necrosis3000300100000

ODI7331226352400

Pi: Pathological index of each lesion according to their importance to organ function [38].
𝑁 O L : number of fishes displaying one type of organ lesion (OL).
*ODI: sum of lesions observed for each organ taking into account their relative severity and the number of fishes ( 𝑁 O L ).