BioMed Research International

Research Article

A Standardized Extract of Ginkgo biloba Neutralizes Cisplatin-Mediated Reproductive Toxicity in Rats

Table 2

The effect of the GB extracts on oxidative stress parameters associated with CIS treatment in testicular tissues of rats.
ParametersNGBCISCIS+LCIS+MCIS+H
MDA (nmol/mg protein) 0 . 9 7 ± 0 . 0 3 0 . 8 6 ± 0 . 0 8 1 . 2 ± 0 . 0 8 ∗ ∗ ∗ 1 . 0 ± 0 . 0 7 c 0 . 8 4 ± 0 . 0 6 a 0 . 9 8 ± 0 . 0 5 c
MPO (mu/mg protein) 1 6 . 9 2 ± 0 . 3 4 1 7 . 1 3 ± 0 . 3 1 2 4 . 6 5 ± 2 . 2 ∗ ∗ ∗ 1 8 . 8 8 ± 0 . 9 3 b 1 9 . 6 9 ± 1 . 5 4 c 1 6 . 9 3 ± 0 . 5 9 c
CAT (u/mg protein) 1 4 6 . 7 9 ± 2 . 9 1 4 4 . 0 7 ± 2 . 0 3 8 4 . 8 9 ± 3 . 2 4 ∗ ∗ ∗ 1 2 7 . 9 ± 3 . 9 ∗ ∗ ∗ a 1 1 8 . 0 ± 3 . 6 4 ∗ ∗ ∗ a 1 3 4 . 4 ± 1 . 8 8 ∗ a
SOD (u/mg protein) 3 . 3 7 ± 0 . 0 2 3 . 3 7 ± 0 . 0 1 3 . 6 2 ± 0 . 0 5 ∗ ∗ ∗ 3 . 2 6 ± 0 . 0 8 a 3 . 1 6 ± 0 . 0 9 a 3 . 2 5 ± 0 . 0 6 a
Values are expressed as mean ± SEM of eight rats per group. Concentration is expressed as nmol/mg protein for MDA. Activity is expressed as unit/mg protein for CAT and SOD. Activity is expressed as m unit/mg protein for MPO. Significance was determined by one-way analysis of variance followed by Dennett’s 𝑡 -test: ∗ 𝑃 < 0 . 0 5 ; ∗ ∗ ∗ 𝑃 < 0 . 0 0 1 versus control. c 𝑃 < 0 . 0 5 ; b 𝑃 < 0 . 0 1 ; a 𝑃 < 0 . 0 0 1 versus CIS group.