Review Article
Factors of the Lectin Pathway of Complement Activation and Their Clinical Associations in Neonates
Table 2
Some clinical associations of selected complement lectin pathway factors, based on own investigation.
| | LP factor | Parameter | Clinical associations | Reference | | Perinatal infections | Preterm/premature births1 | Low birth weight2 |
| | MBL | Low cord serum concentration (<150 ng/mL) | no | no | no | [30] | | Genotype (promoter & exon 1) | XA/O and O/O | A/A (prematurity) | no | | | MASP-2 | Low cord serum concentration (<42 ng/mL) | no | yes | yes | [31] | | Genotype (D120G dimorphism) | no | no | no | | | MBL-MASP-2 complex activity | Low cord serum activity (<60 mU/mL) | no | yes | no | [30] | | L-ficolin | Low cord serum concentrations (<1 μg/mL) | yes | yes | yes | [30] | | H-ficolin | Low cord serum concentrations (<8.6 μg/mL) | no | yes | yes | [36] | | Genotype (1637delC frameshift mutation) | no | no | no | |
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1 Preterm births: gestational age ≤ 37 weeks; premature births: gestational age 35 weeks.
2 Low birthweight: <2500 g.
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