Table 2: Biodistribution results for 111In-DOTA-AgRP-7C in nude mice bearing subcutaneous U87MG human glioblastoma xenografts. Data are expressed as the percent injected dose per gram of tissue (%ID/g) after intravenous injection of the probe (0.259–0.37 MBq, 7–10 μCi) at 0.5, 2, 24, and 48 h ( 𝑛 = 3 ). For 2 h blocking group, mice were coinjected with 330 μg of c(RGDyK).

Tissues0.5 h2 h24 h48 h2 h Blocking

%ID/g
 Tumor 5 . 7 4 ± 1 . 6 0 2 . 3 5 ± 0 . 3 6 1 . 2 9 ± 0 . 0 2 0 . 7 6 ± 0 . 1 7 0 . 5 4 ± 0 . 0 7
 Brain 0 . 0 4 ± 0 . 0 2 0 . 0 2 ± 0 . 0 1 0 . 0 1 ± 0 . 0 0 0 . 0 1 ± 0 . 0 1 0 . 0 1 ± 0 . 0 0
 Blood 0 . 6 8 ± 0 . 2 6 0 . 1 0 ± 0 . 0 2 0 . 0 1 ± 0 . 0 0 0 . 0 1 ± 0 . 0 0 0 . 0 7 ± 0 . 0 1
 Heart 0 . 4 5 ± 0 . 1 6 0 . 1 2 ± 0 . 0 2 0 . 0 4 ± 0 . 0 1 0 . 0 3 ± 0 . 0 0 0 . 0 6 ± 0 . 0 1
 Lung 2 . 1 1 ± 0 . 6 5 0 . 8 6 ± 0 . 2 0 0 . 2 6 ± 0 . 0 9 0 . 1 2 ± 0 . 0 2 0 . 4 1 ± 0 . 0 8
 Liver 0 . 8 0 ± 0 . 1 9 0 . 4 3 ± 0 . 1 6 0 . 2 4 ± 0 . 0 3 0 . 1 9 ± 0 . 0 3 0 . 2 0 ± 0 . 0 4
 Spleen 1 . 7 0 ± 0 . 6 2 0 . 8 8 ± 0 . 2 1 0 . 5 8 ± 0 . 0 9 0 . 4 6 ± 0 . 1 0 0 . 2 1 ± 0 . 0 3
 Kidneys 3 3 . 9 3 ± 8 . 3 5 3 0 . 5 9 ± 4 . 6 2 1 9 . 1 2 ± 2 . 1 7 8 . 4 7 ± 0 . 0 4 3 4 . 5 2 ± 4 . 0 2
 Muscle 0 . 3 0 ± 0 . 1 3 0 . 0 6 ± 0 . 0 1 0 . 0 4 ± 0 . 0 1 0 . 0 2 ± 0 . 0 1 0 . 1 0 ± 0 . 1 0
 Pancreas 0 . 4 2 ± 0 . 1 7 0 . 1 3 ± 0 . 0 3 0 . 0 9 ± 0 . 0 1 0 . 0 5 ± 0 . 0 1 0 . 1 3 ± 0 . 0 3
 Bone 1 . 4 1 ± 0 . 3 6 0 . 6 3 ± 0 . 0 5 0 . 3 9 ± 0 . 0 7 0 . 2 4 ± 0 . 0 5 0 . 4 5 ± 0 . 0 1
 Stomach 2 . 1 7 ± 0 . 4 9 0 . 8 0 ± 0 . 0 6 0 . 2 1 ± 0 . 0 1 0 . 1 4 ± 0 . 0 2 0 . 2 4 ± 0 . 0 4
 Intestine 2 . 0 2 ± 0 . 7 1 0 . 6 0 ± 0 . 1 3 0 . 2 9 ± 0 . 0 2 0 . 2 2 ± 0 . 0 3 0 . 2 5 ± 0 . 0 6
Ratio
 Tumor-to-blood 8 . 9 0 ± 3 . 0 9 2 5 . 8 1 ± 1 0 . 4 6 1 2 7 . 5 3 ± 3 0 . 5 0 1 4 4 . 1 2 ± 3 6 . 3 3 8 . 1 8 ± 0 . 1 5
 Tumor-to-muscle 2 0 . 5 6 ± 6 . 4 0 3 9 . 8 3 ± 9 . 1 6 3 7 . 6 9 ± 9 . 8 1 4 1 . 1 2 ± 8 . 6 2 1 4 . 0 3 ± 1 3 . 4 5

𝑃 < 0 . 0 5 compared with 111In-DOTA-AgRP-7C without c(RGDyK) blocking at 2 h. Data are presented as mean ± SD ( 𝑛 = 3 ).