-Labeled Cystine-Knot Peptides Based on the Agouti-Related Protein for Targeting Tumor Angiogenesis
Table 2
Biodistribution results for 111In-DOTA-AgRP-7C in nude mice bearing subcutaneous U87MG human glioblastoma xenografts. Data are expressed as the percent injected dose per gram of tissue (%ID/g) after intravenous injection of the probe (0.259–0.37 MBq, 7–10 μCi) at 0.5, 2, 24, and 48 h (). For 2 h blocking group, mice were coinjected with 330 μg of c(RGDyK).
Tissues
0.5 h
2 h
24 h
48 h
2 h Blocking
%ID/g
Tumor
Brain
Blood
Heart
Lung
Liver
Spleen
Kidneys
Muscle
Pancreas
Bone
Stomach
Intestine
Ratio
Tumor-to-blood
Tumor-to-muscle
compared with 111In-DOTA-AgRP-7C without c(RGDyK) blocking at 2 h. Data are presented as mean ± SD ().