Table 3: Biodistribution results for 111In-DOTA-AgRP-6E in nude mice bearing subcutaneous U87MG human glioblastoma xenografts. Data are expressed as the percent %ID/g after intravenous injection of the probe (0.296–0.444 MBq, 8–12 μCi) at 0.5, 2, and 24 h ( 𝑛 = 3 ).

Tissue 0.5 h 2 h 24 h

%ID/g
 Tumor 1 . 7 6 ± 0 . 3 4 1 . 2 1 ± 0 . 2 1 0 . 8 9 ± 0 . 0 6
 Brain 0 . 0 6 ± 0 . 0 1 0 . 0 2 ± 0 . 0 1 0 . 0 2 ± 0 . 0 1
 Blood 1 . 2 7 ± 0 . 5 3 0 . 0 6 ± 0 . 0 5 0 . 0 1 ± 0 . 0 0
 Heart 0 . 8 0 ± 0 . 2 4 0 . 1 8 ± 0 . 0 6 0 . 1 2 ± 0 . 0 2
 Lung 1 . 8 6 ± 0 . 5 6 0 . 5 4 ± 0 . 1 2 0 . 2 7 ± 0 . 0 2
 Liver 0 . 8 7 ± 0 . 2 0 0 . 5 2 ± 0 . 0 1 0 . 4 8 ± 0 . 0 2
 Spleen 1 . 3 6 ± 0 . 2 6 0 . 8 3 ± 0 . 0 5 0 . 6 5 ± 0 . 0 6
 Kidneys 1 5 . 3 7 ± 3 . 1 9 1 4 . 6 8 ± 1 . 9 8 6 . 8 7 ± 1 . 1 9
 Muscle 0 . 6 4 ± 0 . 0 9 0 . 1 5 ± 0 . 0 7 0 . 0 7 ± 0 . 0 1
 Pancreas 0 . 5 7 ± 0 . 2 3 0 . 2 0 ± 0 . 0 6 0 . 1 4 ± 0 . 0 1
 Bone 1 . 1 8 ± 0 . 1 5 0 . 5 6 ± 0 . 1 0 0 . 3 6 ± 0 . 0 4
 Stomach 2 . 0 2 ± 0 . 4 7 0 . 8 7 ± 0 . 1 4 0 . 5 3 ± 0 . 0 2
 Intestine 2 . 0 4 ± 0 . 5 4 1 . 1 3 ± 0 . 1 4 0 . 9 3 ± 0 . 0 4
Ratio
 Tumor-to-blood 1 . 7 1 ± 1 . 2 1 3 3 . 0 4 ± 2 3 . 2 8 1 4 2 . 3 2 ± 3 . 3 9
 Tumor-to-muscle 2 . 7 5 ± 0 . 2 8 9 . 2 0 ± 3 . 8 8 1 3 . 0 7 ± 1 . 9 4

Data are presented as mean ± SD ( 𝑛 = 3 ).