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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 413767, 6 pages
http://dx.doi.org/10.1155/2012/413767
Review Article

Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease

1Department of Dermatopathology, University Hospital of Liège, 4000 Liège, Belgium
2San Gallicano Dermatological Institute, 00144 Roma, Italy
3Department of Dermatology, Regional Hospital Citadelle, 4000 Liège, Belgium
4Department of Dermatology, Regional Hospital of Huy, 4500 Huy, Belgium

Received 30 April 2012; Accepted 1 August 2012

Academic Editor: Philippe Humbert

Copyright © 2012 Trinh Hermanns-Lê et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations.