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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 417652, 13 pages
Effect of Marine Omega 3 Fatty Acids on Methylmercury-Induced Toxicity in Fish and Mammalian Cells In Vitro
1National Institute of Nutrition and Research (NIFES), P.O. Box 2029 Nordnes, 5817 Bergen, Norway
2Department of Molecular Biology, University of Bergen, 5020 Bergen, Norway
Received 6 January 2012; Accepted 29 February 2012
Academic Editor: Marcelo Farina
Copyright © 2012 O. J. Nøstbakken et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. Jensen and A. Jernelöv, “Biological methylation of mercury in aquatic organisms,” Nature, vol. 223, no. 5207, pp. 753–754, 1969.
- F. M. M. Morel, A. M. L. Kraepiel, and M. Amyot, “The chemical cycle and bioaccumulation of mercury,” Annual Review of Ecology and Systematics, vol. 29, pp. 543–566, 1998.
- S. Diez, “Human health effects of methylmercury exposure,” Reviews of Environmental Contamination and Toxicology, vol. 198, pp. 111–132, 1998.
- A. F. Castoldi, T. Coccini, S. Ceccatelli, and L. Manzo, “Neurotoxicity and molecular effects of methylmercury,” Brain Research Bulletin, vol. 55, no. 2, pp. 197–203, 2001.
- A. F. Castoldi, T. Coccini, and L. Manzo, “Neurotoxic and molecular effects of methylmercury in humans,” Reviews on Environmental Health, vol. 18, no. 1, pp. 19–31, 2003.
- L. Chapman and H. M. Chan, “The influence of nutrition on methyl mercury intoxication,” Environmental Health Perspectives, vol. 108, supplement 1, pp. 29–56, 2000.
- M. Aschner, T. Syversen, D. O. Souza, J. B. T. Rocha, and M. Farina, “Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity,” Brazilian Journal of Medical and Biological Research, vol. 40, no. 3, pp. 285–291, 2007.
- K. Berg, P. Puntervoll, S. Valdersnes, and A. Goksøyr, “Responses in the brain proteome of Atlantic cod (Gadus morhua) exposed to methylmercury,” Aquatic Toxicology, vol. 100, no. 1, pp. 51–65, 2010.
- M. H. G. Berntssen, A. Aatland, and R. D. Handy, “Chronic dietary mercury exposure causes oxidative stress, brain lesions, and altered behaviour in Atlantic salmon (Salmo salar) parr,” Aquatic Toxicology, vol. 65, no. 1, pp. 55–72, 2003.
- T. K. Garg and J. Y. Chang, “Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12, 14-prostaglandin J2,” Journal of Neuroimmunology, vol. 171, no. 1-2, pp. 17–28, 2006.
- C. Johansson, A. F. Castoldi, N. Onishchenko, L. Manzo, M. Vahter, and S. Ceccatelli, “Neurobehavioural and molecular changes induced by methylmercury exposure during development,” Neurotoxicity Research, vol. 11, no. 3-4, pp. 241–260, 2007.
- M. E. Crespo-López, A. Lima de Sá, A. M. Herculano, R. Rodríguez Burbano, and J. L. Martins do Nascimento, “Methylmercury genotoxicity: a novel effect in human cell lines of the central nervous system,” Environment International, vol. 33, no. 2, pp. 141–146, 2007.
- K. Miura and N. Imura, “Mechanism of methylmercury cytotoxicity,” Critical Reviews in Toxicology, vol. 18, no. 3, pp. 161–188, 1987.
- C. Bouzan, J. T. Cohen, W. E. Connor et al., “A quantitative analysis of fish consumption and stroke risk,” American Journal of Preventive Medicine, vol. 29, no. 4, pp. 347–352, 2005.
- J. T. Cohen, D. C. Bellinger, W. E. Connor et al., “A quantitative risk-benefit analysis of changes in population fish consumption,” American Journal of Preventive Medicine, vol. 29, no. 4, pp. 325–334, 2005.
- G. L. Ginsberg and B. F. Toal, “Quantitative approach for incorporating methylmercury risks and omega-3 fatty acid benefits in developing species-specific fish consumption advice,” Environmental Health Perspectives, vol. 117, no. 2, pp. 267–275, 2009.
- J. R. Hibbeln, T. A. Ferguson, and T. L. Blasbalg, “Omega-3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for intervention,” International Review of Psychiatry, vol. 18, no. 2, pp. 107–118, 2006.
- G. J. Myers, D. O. Marsh, C. Cox et al., “A pilot neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet,” NeuroToxicology, vol. 16, no. 4, pp. 629–638, 1995.
- G. J. Myers, D. O. Marsh, P. W. Davidson et al., “Main neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet: outcome at six months,” NeuroToxicology, vol. 16, no. 4, pp. 653–664, 1995.
- P. Grandjean, P. Weihe, R. F. White et al., “Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury,” Neurotoxicology and Teratology, vol. 19, no. 6, pp. 417–428, 1997.
- G. J. Myers and P. W. Davidson, “Prenatal methylmercury exposure and children: neurologic, developmental, and behavioral research,” Environmental Health Perspectives, vol. 106, supplement 3, pp. 841–847, 1998.
- P. Bjerregaard, B. W. Andersen, and J. C. Rankin, “Retention of methyl mercury and inorganic mercury in rainbow trout Oncorhynchus mykiss (W): effect of dietary selenium,” Aquatic Toxicology, vol. 45, no. 2-3, pp. 171–180, 1999.
- X. Jin, E. Lok, G. Bondy et al., “Modulating effects of dietary fats on methylmercury toxicity and distribution in rats,” Toxicology, vol. 230, no. 1, pp. 22–44, 2007.
- P. Kaur, K. Schulz, M. Aschner, and T. Syversen, “Role of docosahexaenoic acid in modulating methylmercury-induced neurotoxicity,” Toxicological Sciences, vol. 100, no. 2, pp. 423–432, 2007.
- G. T. Hanson, R. Aggeler, D. Oglesbee et al., “Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators,” The Journal of Biological Chemistry, vol. 279, no. 13, pp. 13044–13053, 2004.
- C. Ghioni, D. R. Tocher, and J. R. Sargent, “The effect of culture on morphology, lipid and fatty acid composition, and polyunsaturated fatty acid metabolism of rainbow trout (Oncorhynchus mykiss) skin cells,” Fish Physiology and Biochemistry, vol. 16, no. 6, pp. 499–513, 1997.
- Roche-Diagnostics-GmbH, RTCA SP Instrument Operator's Manual, ACEA Biosciences, 2009.
- E. Urcan, U. Haertel, M. Styllou, R. Hickel, H. Scherthan, and F. X. Reichl, “Real-time xCELLigence impedance analysis of the cytotoxicity of dental composite components on human gingival fibroblasts,” Dental Materials, vol. 26, no. 1, pp. 51–58, 2010.
- P. A. Olsvik, F. Kroglund, B. Finstad, and T. Kristensen, “Effects of the fungicide azoxystrobin on Atlantic salmon (Salmo salar L.) smolt,” Ecotoxicology and Environmental Safety, vol. 73, no. 8, pp. 1852–1861, 2010.
- J. Vandesompele, K. De Preter, F. Pattyn et al., “Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes,” Genome Biology, vol. 3, no. 7, 2002.
- R. Klaper, B. J. Carter, C. A. Richter, P. E. Drevnick, M. B. Sandheinrich, and D. E. Tillitt, “Use of a 15 k gene microarray to determine gene expression changes in response to acute and chronic methylmercury exposure in the fathead minnow Pimephales promelas Rafinesque,” Journal of Fish Biology, vol. 72, no. 9, pp. 2207–2280, 2008.
- G. Jogl, Y. S. Hsiao, and L. Tong, “Structure and function of carnitine acyltransferases,” Annals of the New York Academy of Sciences, vol. 1033, pp. 17–29, 2004.
- J. P. Bonnefont, F. Djouadi, C. Prip-Buus, S. Gobin, A. Munnich, and J. Bastin, “Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects,” Molecular Aspects of Medicine, vol. 25, no. 5-6, pp. 495–520, 2004.
- J. E. Schaffer and H. F. Lodish, “Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein,” Cell, vol. 79, no. 3, pp. 427–436, 1994.
- B. I. Frohnert and D. A. Bernlohr, “Regulation of fatty acid transporters in mammalian cells,” Progress in Lipid Research, vol. 39, no. 1, pp. 83–107, 2000.
- D. Sebastián, M. Guitart, C. García-Martínez et al., “Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells,” Journal of Lipid Research, vol. 50, no. 9, pp. 1789–1799, 2009.
- J. P. Bourdineaud, S. Cambier, G. Bénard et al., “At environmental doses, dietary methylmercury inhibits mitochondrial energy metabolism in skeletal muscles of the zebra fish (Danio rerio),” International Journal of Biochemistry and Cell Biology, vol. 41, no. 4, pp. 791–799, 2009.
- S. Yee and B. H. Choi, “Oxidative stress in neurotoxic effects of methylmercury poisoning,” NeuroToxicology, vol. 17, no. 1, pp. 17–26, 1996.
- G. Shanker, R. E. Hampson, and M. Aschner, “Methylmercury stimulates arachidonic acid release and cytosolic phospholipase A2 expression in primary neuronal cultures,” NeuroToxicology, vol. 25, no. 3, pp. 399–406, 2004.
- P. Rockwell, J. Martinez, L. Papa, and E. Gomes, “Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium,” Cellular Signalling, vol. 16, no. 3, pp. 343–353, 2004.
- Y. Sun, J. Chen, and B. Rigas, “Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death,” Carcinogenesis, vol. 30, no. 1, pp. 93–100, 2009.
- H. Tokuda, M. Miwa, Y. Oiso, and O. Kozawa, “Autoregulation of prostaglandin E2-induced Ca2+ influx in osteoblast-like cells: inhibition by self-induced activation of protein kinase C,” Cellular Signalling, vol. 4, no. 3, pp. 261–266, 1992.
- M. Sue Marty and W. D. Atchison, “Pathways mediating Ca2+ entry in rat cerebellar granule cells following in vitro exposure to methyl mercury,” Toxicology and Applied Pharmacology, vol. 147, no. 2, pp. 319–330, 1997.
- A. A. Spector, “Essentiality of fatty acids,” Lipids, vol. 34, no. 6, supplement 3, pp. S1–S3, 1999.
- P. C. Calder, “n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases,” American Journal of Clinical Nutrition, vol. 83, no. 6, supplement, pp. 1505S–1519S, 2006.
- D. Bagga, L. Wang, R. Farias-Eisner, J. A. Glaspy, and S. T. Reddy, “Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 4, pp. 1751–1756, 2003.
- D. Grotto, J. Vicentini, J. P. Friedmann Angeli et al., “Evaluation of protective effects of fish oil against oxidative damage in rats exposed to methylmercury,” Ecotoxicology and Environmental Safety, vol. 74, no. 3, pp. 487–493, 2011.
- M. A. Kjaer, M. Todorcević, B. E. Torstensen, A. Vegusdal, and B. Ruyter, “Dietary n-3 HUFA affects mitochondrial fatty acid beta-oxidation capacity and susceptibility to oxidative stress in Atlantic salmon,” Lipids, vol. 43, no. 9, pp. 813–827, 2008.
- T. K. Østbye, M. A. Kjær, A. M. B. Rørå, B. Torstensen, and B. Ruyter, “High n-3 HUFA levels in the diet of Atlantic salmon affect muscle and mitochondrial membrane lipids and their susceptibility to oxidative stress,” Aquaculture Nutrition, vol. 17, no. 2, pp. 177–190, 2011.
- N. Nakamura, R. Kumasaka, H. Osawa et al., “Effects of eicosapentaenoic acids on oxidative stress and plasma fatty acid composition in patients with lupus nephritis,” In Vivo, vol. 19, no. 5, pp. 879–882, 2005.
- P. Kaur, I. Heggland, M. Aschner, and T. Syversen, “Docosahexaenoic acid may act as a neuroprotector for methylmercury-induced neurotoxicity in primary neural cell cultures,” NeuroToxicology, vol. 29, no. 6, pp. 978–987, 2008.
- W. Wang, T. W. Clarkson, and N. Ballatori, “γ-Glutamyl transpeptidase and L-Cysteine regulate methylmercury uptake by HepG2 cells, a human hepatoma cell line,” Toxicology and Applied Pharmacology, vol. 168, no. 1, pp. 72–78, 2000.
- R. Gorjão, A. K. Azevedo-Martins, H. G. Rodrigues et al., “Comparative effects of DHA and EPA on cell function,” Pharmacology and Therapeutics, vol. 122, no. 1, pp. 56–64, 2009.
- M. Shimazawa, Y. Nakajima, Y. Mashima, and H. Hara, “Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells,” Brain Research, vol. 1251, pp. 269–275, 2009.
- K. S. Kang, P. Wang, N. Yamabe, M. Fukui, T. Jay, and B. T. Zhu, “Docosahexaenoic acid induces apoptosis in MCF-7 cells In Vitro and In Vivo via reactive oxygen species formation and caspase 8 activation,” PLoS One, vol. 5, no. 4, Article ID e10296, 2010.
- C. P. Lebel, S. F. Ali, M. McKee, and S. C. Bondy, “Organometal-induced increases in oxygen reactive species: the potential of ,-dichlorofluorescin diacetate as an index of neurotoxic damage,” Toxicology and Applied Pharmacology, vol. 104, no. 1, pp. 17–24, 1990.