The Impact of Caesarean Delivery on Paracetamol and Ketorolac Pharmacokinetics: A Paired Analysis

Table 2

Clinical characteristics and pharmacokinetic estimates for intravenous ketorolac (single dose, 30 mg) in 8 women as collected at delivery and in postpartum (17–23 weeks after delivery). Data provided by median and range.

	At delivery	Postpartum	𝑃 value
Body weight (kg)	75.5 (60–85)	60.8 (48.8–87.2)	𝑃=0.0156
Body surface area, BSA (m^2)	1.89 (1.65–1.98)	1.69 (1.48–2.01)	𝑃=0.0156
Clearance (L/h)	3.8 (2.68–4.50)	2.53 (1.4–3.02)	𝑃=0.0078
Clearance (L/h·kg)	0.05 (0.03–0.07)	0.04 (0.02–0.06)	𝑃=0.0469
Clearance/BSA (L/h·m^2)	2.03 (1.35–2.66)	1.43 (0.88–1.83)	𝑃=0.0391
Distribution volume (L)	14.6 (10.8–27.7)	10.88 (6.94–14.01)	𝑃=0.0156
Distribution volume (L/kg)	0.19 (0.15–0.38)	0.16 (0.11–0.24)	𝑃=0.0391
Elimination half-life (h)	3.08 (1.85–4.79)	2.84 (2.28–5.11)	n.s.