Lysine Acetylation: Elucidating the Components of an Emerging Global Signaling Pathway in Trypanosomes

Figure 1

MYST family histone acetyltransferase orthologues in trypanosomatids. Multiple sequence alignments of the core acetyltransferase domains from Tritryps and other organisms. Sequences were aligned with ClustalX2 followed by manual adjustment and illustrated with ESPript 2.2. Identical residues are white on red background, and residues shared by some organisms are black on yellow background. Asterisks indicate residues that were predicted to form part of the catalytic pocket. The gray box marks the C2HC zinc-binding domain. Motif A that binds acetyl Co-A is indicated with a green box. Tb, Trypanosoma brucei; Tc, Trypanosoma cruzi; Lm, Leishmania mayor; At, Arabidopsis thaliana; Hs, human; Sc, Saccharomyces cerevisiae; AcuC, acetoin utilization.