Lysine Acetylation: Elucidating the Components of an Emerging Global Signaling Pathway in Trypanosomes

Figure 2

GNAT family histone acetyltransferases orthologues in trypanosomatids. Multiple sequence alignments of the core acetyltransferase domains from Tritryps and other organisms. Sequences were aligned with ClustalX2 followed by manual adjustment and illustrated with ESPript 2.2. Identical residues are white on red background, and residues shared by some organisms are black on yellow background. Radical SAM domain (blue box) and GNAT-type acetyltransferase domain (black box) are indicated. Motif A is marked with a green box. Arrowheads indicate the Cys residues that are part of the Fe-S cluster in the SAM domain. Tb, Trypanosoma brucei; Tc, Trypanosoma cruzi; Lm, Leishmania mayor; At, Arabidopsis thaliana; Hs, human; Sc, Saccharomyces scerevisiae: Tt, Tetraymena thermophila.