Lysine Acetylation: Elucidating the Components of an Emerging Global Signaling Pathway in Trypanosomes

Figure 5

Class III deacetylases orthologues in trypanosomatids. Multiple sequence alignments of the core deacetylase domains from Tritryps and other organisms. Sequences were aligned with ClustalX2 followed by manual adjustment and illustrated with ESPript 2.2. Identical residues are white on red background and residues shared by some organisms are black on yellow background. Asterisks indicate residues that were predicted to form part of the catalytic pocket. The grey box marks the C2HC zinc-binding domain. Circles indicate NAD⁺-binding residues and asterisks indicate catalytic residues. The GAD and NID motifs as well as the conserved HG residues important for catalysis are underlined. Tb, Trypanosoma brucei; Tc, Trypanosoma cruzi; Lm, Leishmania mayor; At, Arabidopsis thaliana; Hs, human; Sc, Saccharomyces cerevisiae; Sy, Synechocystis spp.