Review Article
Lysine Acetylation: Elucidating the Components of an Emerging Global Signaling Pathway in Trypanosomes
Table 2
Lysine acetyltransferases (KATs) present in Tritryps.
| Acetyltransferase | Accession numbers | Family | Subcellular localization | Comments |
Reference | T. brucei | L. major | T. cruzi |
| HAT1 | Tb927.7.4560 | LmjF14.0140 | Tc00.1047053506605.160 Tc00.1047053511239.150 | MYST | Nuclear (T. brucei) | Essential for growth, required for telomeric silencing | Kawahara et al., 2008 [34] | HAT2 | Tb11.01.3380 | LmjF28.2270 | Tc00.1047053511017.69 Tc00.1047053509203.60 | MYST | Nuclear (T. brucei) | Essential for growth, responsible for H4K10 acetylation | Kawahara et al., 2008 [34] | HAT3 | Tb927.10.8310 | LmjF36.6990 | Tc00.1047053507611.290 Tc00.1047053507723.110 | MYST | Nuclear (T. brucei) | Not essential for growth, responsible for H4K4 acetylation | Kawahara et al., 2008 [34] | HAT4 | | LmjF13.0170 | Tc00.1047053506227.160 | MYST | Cytoplasmic in all life cycle stages, nuclear in postmitotic cells (L. donovani) | Acetylates histone H4 | Kumar et al., 2012 [35] | ELP3a | Tb927.8.5770 | LmjF16.0240 | Tc00.1047053506743.120 Tc00.1047053503851.10 | GNAT | Nuclear periphery (T. brucei) | | Alsford and Horn, 2011 [36] | ELP3b | Tb927.8.3310 | LmjF23.1350 | Tc00.1047053509769.110 | GNAT | Nucleolar (T. brucei) | Controls rDNA transcription | Alsford and Horn, 2011 [36] |
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