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Figure 2: Schematic representation of asbestos-induced reduction of expression of a chemokine receptor, CXCR3, and expression and production of IFN-γ with increasing IL-6 using the MT-2 cell line model exposed continuously to a low dose of chrysotile (upper left), an ex vivo exposure model using freshly isolated CD4+ T cells from healthy donors (HD) (lower left) as well as analyses of freshly isolated CD4+ T cells from healthy donors and patients with pleural plaque (PP) and malignant mesothelioma (MM) (right).