Detection of Target ssDNA Using a Microfabricated Hall Magnetometer with Correlated Optical Readout

Figure 1

Generalized schematic for the detection of label-free target DNA using Hall magnetometry. The label-free target DNA (black) is detected by immobilization at the Hall device via complementary base pairing with receptor DNA (blue) preassembled on the Hall device surface to additional complementary probe DNA (red) with an internal fluorescent marker preconjugated to the surface of a magnetic nanobead resulting in a detectable Hall signal. Nanobead is not drawn to scale.