About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 498051, 8 pages
http://dx.doi.org/10.1155/2012/498051
Research Article

Food Supplement 20070721-GX May Increase CD34+ Stem Cells and Telomerase Activity

1Center for Neuropsychiatry and Department of Neurosurgery, China Medical University Hospital, 2 Yuh-Der Road, Taichung 40447, Taiwan
2Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan
3Graduate Institute of Chinese Medicine, China Medical University, Taichung 40447, Taiwan
4Tzu Chi Stem Cells Centre, Buddhist Tzu Chi General Hospital, Hualien 97002, Taiwan
5Department of Stem Cell Applied Technology, Gwo Xi Stem Cell Applied Technology, Hsinchu 30261, Taiwan
6Graduate Institute of Immunology, China Medical University, Taichung 40447, Taiwan
7Department of Neurosurgery, China Medical University Beigan Hospital, Yunlin 65152, Taiwan
8Department of Pathology, China Medical University Hospital, 2 Yuh-Der Road, Taichung 40447, Taiwan
9Department of Medicine, China Medical University, Taichung 40447, Taiwan

Received 25 May 2011; Revised 1 February 2012; Accepted 1 February 2012

Academic Editor: Michael J. Spinella

Copyright © 2012 Po-Cheng Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. J. Kim, J. W. Lee, Y. L. Kim, and M. H. Lee, “The effect of placental extract on the expression of tyrosinase, TRP-1 and TRP-2 in SK30 melanoma cells,” Korean Journal of Dermatology, vol. 41, no. 12, pp. 1612–1618, 2003. View at Scopus
  2. S. Togashi, N. Takahashi, M. Iwama, S. Watanabe, K. Tamagawa, and T. Fukui, “Antioxidative collagen-derived peptides in human-placenta extract,” Placenta, vol. 23, no. 6, pp. 497–502, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Tonello, M. Daglio, N. Zaccarelli, E. Sottofattori, M. Mazzei, and A. Balbi, “Characterization and quantitation of the active polynucleotide fraction (PDRN) from human placenta, a tissue repair stimulating agent,” Journal of Pharmaceutical and Biomedical Analysis, vol. 14, no. 11, pp. 1555–1560, 1996. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. K. Lee, H. H. Chung, and S. B. Kang, “Efficacy and safety of human placenta extract in alleviating climacteric symptoms: prospective, randomized, double-blind, placebo-controlled trial,” Journal of Obstetrics and Gynaecology Research, vol. 35, no. 6, pp. 1096–1101, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Sabapatha, C. Gercel-taylor, and D. D. Taylor, “Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences,” American Journal of Reproductive Immunology, vol. 56, no. 5-6, pp. 345–355, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. K. C. Hooper, “The action of inhibitors on enzymes from human placentae,” The Journal of Physiology, vol. 148, pp. 283–290, 1959. View at Scopus
  7. M. Uszynski, “Anticoagulant activity of peptides from the human placenta,” Thrombosis Research, vol. 16, no. 5-6, pp. 689–694, 1979. View at Scopus
  8. H. Mochizuki and T. Kada, “Antimutagenic action of mammalian placental extracts on mutations induced in Escherichia coli by UV radiation, gamma-rays and N-methyl-N′-nitro-N-nitrosoguanidine,” Mutation Research, vol. 95, no. 2-3, pp. 457–474, 1982. View at Scopus
  9. S. Watanabe, S. I. Togashi, N. Takahashi, and T. Fukui, “L-tryptophan as an antioxidant in human placenta extract,” Journal of Nutritional Science and Vitaminology, vol. 48, no. 1, pp. 36–39, 2002. View at Scopus
  10. A. Jang, C. Jo, I.-J. Kim, and M. Lee, “Nutritional quality of dried pig placenta,” Journal of Food Science and Nutrition, vol. 12, pp. 89–94, 2007.
  11. D. E. Harrison, C. M. Astle, and J. A. Delaittre, “Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging,” Journal of Experimental Medicine, vol. 147, no. 5, pp. 1526–1531, 1978. View at Scopus
  12. D. R. Boggs, J. C. Marsh, P. A. Chervenick, G. E. Cartwright, and M. M. Wintrobe, “Factors influencing hematopoietic spleen colony formation in irradiated mice. 3. The effect of repetitive irradiation upon proliferative ability of colony-forming cells,” Journal of Experimental Medicine, vol. 126, no. 5, pp. 871–880, 1967. View at Scopus
  13. H. Vaziri, W. Dragowska, R. C. Allsopp, T. E. Thomas, C. B. Harley, and P. M. Lansdorp, “Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 21, pp. 9857–9860, 1994. View at Publisher · View at Google Scholar · View at Scopus
  14. G. M. Baerlocher, A. Roth, and P. M. Lansdorp, “Telomeres in hematopoietic stem cells,” Annals of the New York Academy of Sciences, vol. 996, pp. 44–48, 2003. View at Scopus
  15. R. G. Shaffer, S. Greene, A. Arshi et al., “Effect of acute exercise on endothelial progenitor cells in patients with peripheral arterial disease,” Vascular Medicine, vol. 11, no. 4, pp. 219–226, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Rothstein, “Disordered hematopoiesis and myelodysplasia in the elderly,” Journal of the American Geriatrics Society, vol. 51, no. 3, supplement, pp. S22–S26, 2003. View at Scopus
  17. Y. Egusa, Y. Fujiwara, E. Syahruddin, T. Isobe, and M. Yamakido, “Effect of age on human peripheral blood stem cells,” Oncology Reports, vol. 5, no. 2, pp. 397–400, 1998. View at Scopus
  18. R. Moresi, S. Tesei, L. Costarelli et al., “Age- and gender-related alterations of the number and clonogenic capacity of circulating CD34+ progenitor cells,” Biogerontology, vol. 6, no. 3, pp. 185–192, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. C. C. Lee, M. D. Fletcher, and A. F. Tarantal, “Effect of age on the frequency, cell cycle, and lineage maturation of rhesus monkey (Macaca mulatta) CD34+ and hematopoietic progenitor cells,” Pediatric Research, vol. 58, no. 2, pp. 315–322, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Kenyon, “The plasticity of aging: insights from long-lived mutants,” Cell, vol. 120, no. 4, pp. 449–460, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Kenyon, “A conserved regulatory system for aging,” Cell, vol. 105, no. 2, pp. 165–168, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Dupont and D. LeRoith, “Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction,” Hormone Research, vol. 55, supplement 2, pp. 22–26, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. D. LeRoith and O. Gavrilova, “Mouse models created to study the pathophysiology of Type 2 diabetes,” International Journal of Biochemistry and Cell Biology, vol. 38, no. 5-6, pp. 904–912, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. M. S. Bonkowski, J. S. Rocha, M. M. Masternak, K. A. Al Regaiey, and A. Bartke, “Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 20, pp. 7901–7905, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Bartke, “Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging,” Endocrinology, vol. 146, no. 9, pp. 3718–3723, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Yang, M. Anzo, and P. Cohen, “Control of aging and longevity by IGF-I signaling,” Experimental Gerontology, vol. 40, no. 11, pp. 867–872, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. M. L. Vance, “Can growth hormone prevent aging?” The New England Journal of Medicine, vol. 348, no. 9, pp. 779–780, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. S. J. Morrison, K. R. Prowse, P. Ho, and I. L. Weissman, “Telomerase activity in hematopoietic cells is associated with self-renewal potential,” Immunity, vol. 5, no. 3, pp. 207–216, 1996. View at Publisher · View at Google Scholar · View at Scopus
  29. H. W. Lee, M. A. Blasco, G. J. Gottlieb, J. W. Horner II, C. W. Greider, and R. A. DePinho, “Essential role of mouse telomerase in highly proliferative organs,” Nature, vol. 392, no. 6676, pp. 569–574, 1998. View at Publisher · View at Google Scholar · View at Scopus
  30. R. C. Allsopp, H. Vaziri, C. Patterson et al., “Telomere length predicts replicative capacity of human fibroblasts,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 21, pp. 10114–10118, 1992. View at Publisher · View at Google Scholar · View at Scopus
  31. T. von Zglinicki, G. Saretzki, W. Docke, and C. Lotze, “Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?” Experimental Cell Research, vol. 220, no. 1, pp. 186–193, 1995. View at Publisher · View at Google Scholar · View at Scopus
  32. G. A. Ulaner, J. F. Hu, T. H. Vu, L. C. Giudice, and A. R. Hoffman, “Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts,” Cancer Research, vol. 58, no. 18, pp. 4168–4172, 1998. View at Scopus
  33. J. W. Gratama, A. Orfao, D. Barnett et al., “Flow cytometric enumeration of CD34+ hematopoietic stem and progenitor cells . European working group on clinical cell analysis,” Cytometry, vol. 34, no. 3, pp. 128–142, 1998. View at Publisher · View at Google Scholar
  34. N. W. Kim, M. A. Piatyszek, K. R. Prowse et al., “Specific association of human telomerase activity with immortal cells and cancer,” Science, vol. 266, no. 5193, pp. 2011–2015, 1994. View at Scopus
  35. K. Khosrotehrani, K. L. Johnson, D. H. Cha, R. N. Salomon, and D. W. Bianchi, “Transfer of fetal cells with multilineage potential to maternal tissue,” Journal of the American Medical Association, vol. 292, no. 1, pp. 75–80, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. T. X. Chen, Y. Y. Xiong, and L. Liu, “Expression and significance of telomerase reverse transcriptase and its regulators in non-small cell lung carcinoma,” Ai Zheng, vol. 23, no. 3, pp. 273–277, 2004. View at Scopus
  37. S. M. Yang, D. C. Fang, J. L. Yang, L. Chen, Y. H. Luo, and G. P. Liang, “Antisense human telomerase reverse transcriptase could partially reverse malignant phenotypes of gastric carcinoma cell line in vitro,” European Journal of Cancer Prevention, vol. 17, no. 3, pp. 209–217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. C. C. Fu and Z. X. Chen, “Study of telomerase activity in bone marrow cells from patients with myelodysplastic syndromes,” Zhongguo Shi Yan Xue Ye Xue Za Zhi, vol. 9, no. 4, pp. 303–306, 2001.
  39. H. Handa, T. Matsushima, N. Nishimoto et al., “Flow cytometric detection of human telomerase reverse transcriptase (hTERT) expression in a subpopulation of bone marrow cells,” Leukemia Research, vol. 34, no. 2, pp. 177–183, 2010. View at Publisher · View at Google Scholar · View at Scopus