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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 503241, 28 pages
http://dx.doi.org/10.1155/2012/503241
Research Article

The Safety of Cruciferous Plants in Humans: A Systematic Review

1Pediatric Neurosciences, Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Room 3-469, Edmonton Clinic Health Academy (ECHA), 11405-87 Avenue, Edmonton, AB, Canada T6G 1C9
2CARE Program, Department of Pediatrics, University of Alberta, Edmonton Clinic Health Academy (ECHA), 11405-87 Avenue, Edmonton, AB, Canada T6G 1C9
3School of Public Health, University of Alberta, Edmonton Clinic Health Academy (ECHA), 11405-87 Avenue, Edmonton, AB, Canada T6G 1C9

Received 27 July 2011; Accepted 11 October 2011

Academic Editor: Ikhlas A. Khan

Copyright © 2012 Ori Scott et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Some cruciferous plants may serve as preventive treatments for several medical conditions; our objective was to systematically investigate their safety in humans. Four electronic databases were searched, and, of 10,831 references identified, 50 were included. Data were extracted by two independent reviewers, whereafter the association between interventions and adverse events was assessed. Adverse events in 53 subjects were identified through clinical trials; of these, altered drug metabolism was rated as certainly/likely caused by cruciferous plants. Adverse events in 1247 subjects were identified through observational studies, of which none received high causality ratings. Adverse events in 35 subjects were identified through case reports, of which allergies and warfarin resistance were rated as certainly/likely caused by cruciferous plants. We conclude that cruciferous plants are safe in humans, with the exception of allergies. Individuals treated with warfarin should consult their physician. Further investigation of uses of cruciferous plants in preventative medicine is warranted.