|
| Study details | Patient details | Intervention | Outcome |
| Reference | Study design1 | Setting | No. of patients/
comparators2 | Age range | Concurrent conditions/
treatments | Plant/
substance | Route3 | Duration4 | Dose5 | Adverse events6 | Outcome7 | Causality8 |
|
| Fell et al. 1992 [31] | Cohort | Multi-site | 1515 (1478: natural exposure, 37: occupational exposure) | Adults | Atopy in some subjects | Oilseed rape | Respiratory and topical allergy tests | Acute to chronic | NA | In naturally exposed, 4/1478 showed positive skin test and 3/1478 showed positive RAST and nasal sensitivity. In occupationally exposed, 9/37 showed positive skin test and 5/37 showed positive RAST and nasal sensitivity | Not specified | Possibly |
|
| Hemmer et al. 1997 [32] | Cohort | Single site | 4468 | Not given | Suspected inhalant allergy to oilseed rape. Multiple allergies to other pollen allergens | Oilseed rape | Respiratory | 1 year | NA | 147 showed positive skin prick test to oilseed rape | NA | Possibly |
|
| Parrat et al. 1995 [33] | Cohort | Community | 22 | Adults | Not given | Oilseed rape | Respiratory | Seasonal | NA | Allergy (sneezing, coughing, eye irritation) in 10 | Improvement when not exposed | Possibly |
|
| Lerbaek et al. 2004 [36] | Cohort | Hospital | 259 | Not given | Suspected contact allergy to foods containing allyl isothiocyanate | Allyl isothiocyanate 0.1% in petrolatum | Topical allergy test | Acute | NA | In 43patients: ?+ reaction, of whom 15 had irritation and 3 had follicular reaction. Two showed a true + reaction but one lost to follow up | Spontaneous resolution | Possibly |
|
| Sakauchi et al. 2007 [37] | Cohort | Community | 64327 women | 40–79 yrs | Not given | Cabbage, Chinese cabbage, green leafy vegetables, and other foods | Oral | Chronic (exact time frame given) | Varies: 0 times a week to almost every day | No adverse events with consumption of cabbage or green leafy vegetables. Of 100 women who reported moderate-high consumption of Chinese cabbage, 46 had ovarian cancer | Death | Possibly |
|
| Michnovicz and Bradlow 1997 [44] | Cohort | Community | 12 | 22–48 yrs | No history of recent or chronic illness, drug use, or recent changes in weight | Indole-3-carbinol | Oral | 7 days | 5–7 mg/kg/day | No adverse events | NA | NA |
|
| Michaud et al. 2002 [45] | Cohort | Community | 27111 | 50–69 yrs | Male smokers with no history of cancer, not using vitamins A, E or beta-carotene in excess | Cruciferous vegetables | Oral | chronic (reported intake in last 12 months) | NA | No adverse events | NA | NA |
|
| Soutar et al. 1995 [34] | CCS | Hospital | 37/24 | 17–54 yrs | Seasonal allergic symptoms and bronchial reactivity | Oilseed rape | Respiratory | Seasonal | NA | Of the 23 cases tested, only 2 were found to be truly allergic to oilseed rape, and only 10 (including these 2) were atopic | Not mentioned | Possibly (for 2 who are allergic) Unlikely (for the rest) |
|
| Memon et al. 2002 [42] | CCS | Kuwait cancer control center | 313/313 | 5–70 yrs | Cases: thyroid cancer. Either cases or controls: asthma, diabetes mellitus, gall bladder disease, hyper-tension, lupous, polyposis coli, skin allergy, skin disease (not specified) | Cabbage, cauliflower, broccoli | Oral | Chronic (exact time frame given) | Varies: 0 to 7 days a week | No adverse events with consumption of broccoli. 63/101 people with high cabbage consumption and 55/91 people with high cauliflower consumption had thyroid cancer; however, P trends were not statistically significant (0.08 and 0.16, resp.) | Not mentioned | Possibly |
|
| Galanti et al. 1997 [43] | CCS | Community | 246/440 | 18–75 yrs | Not given | White and red cabbages, cauliflower, broccoli, Brusselss sprouts | Oral | Chronic (exact time frame given) | Varies: <2 to >6 times a week | 56/110 people who at anytime lived in areas in Sweden where goiter and iodine deficiency were endemic until the 1960’s and who reported moderate-high consumption of cruciferous vegetables had thyroid cancer | Not mentioned | Possibly |
|
| Soutar et al. 1994 [35] | CSS | Community | 869/867 | 14–50 yrs | Both villages: 448 smokers, 325 ex-smokers | Oilseed rape | Respiratory | Chronic: months | NA | 683 of 869 who were exposed had seasonal cough, wheeze, and headaches | Not mentioned | Possibly |
|
| Sato et al. 2004 [46] | CSS | Community | 438 | 39–60 yrs | No history of gastric cancer or gastric ulcer | Broccoli | Oral | Chronic (exact time frame given) | Varies: never to few times a week | 46/186 people who consumed broccoli once or more a week had changes in enzymes which might indicate chronic atrophic gastritis | Ongoing | Possibly |
|
| Lust et al. 1996 [47] | QS | Community | 273 | <4 mo | Not given | Various foods, including cruciferous vegetables (specifically cabbage, cauliflower, broccoli) | Oral (through breast milk) | Unclear (mothers were asked whether they ate different items the previous week) | Not given | 63/273 exhibited colic symptoms (abdominal pain, irritability, intense crying) | Not mentioned | Possibly |
|
