Temporal and Quantitative Analysis of Atherosclerotic Lesions in Diet-Induced Hypercholesterolemic Rabbits

Figure 4

Immunohistochemical investigations of the lesions. Representative images are shown for macrophages (Mφ) and SMC α-actin (a). Mφ- and SMC-positive areas were determined using an image analysis system (b). The Mφs and SMCs were compared with cholesterol exposure (AUC) and intima lesion area, respectively (c). The data are expressed as the means ± SEM. 𝑛=6−8 for each group. *𝑃<0.05 and **𝑃<0.001.