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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 506159, 7 pages
http://dx.doi.org/10.1155/2012/506159
Research Article

Temporal and Quantitative Analysis of Atherosclerotic Lesions in Diet-Induced Hypercholesterolemic Rabbits

1Research Institute of Atherosclerotic Disease, Xi’an Jiaotong University School of Medicine, Xi'an 710061, China
2Department of Molecular Pathology, University of Yamanashi, Chuo 409-3898, Japan
3Key Laboratory of Environment and Genes Related to Diseases of the Education Ministry, Xi’an Jiaotong University School of Medicine, Shaanxi, Xi'an 710061, China

Received 23 July 2011; Revised 24 November 2011; Accepted 12 December 2011

Academic Editor: George E. Plopper

Copyright © 2012 Qi Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Libby and M. Aikawa, “Stabilization of atherosclerotic plaques: new mechanisms and clinical targets,” Nature Medicine, vol. 8, no. 11, pp. 1257–1262, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Ross, “Atherosclerosis—an inflammatory disease,” New England Journal of Medicine, vol. 340, no. 2, pp. 115–126, 1999. View at Publisher · View at Google Scholar
  3. D. Steinberg, “Hypercholesterolemia and inflammation in atherogenesis: two sides of the same coin,” Molecular Nutrition and Food Research, vol. 49, no. 11, pp. 995–998, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Libby, “Changing concepts of atherogenesis,” Journal of Internal Medicine, vol. 247, no. 3, pp. 349–358, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. M. R. Bennett, “Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture,” Cardiovascular Research, vol. 41, no. 2, pp. 361–368, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. J. J. Boyle, D. E. Bowyer, P. L. Weissberg, and M. R. Bennett, “Human blood-derived macrophages induce apoptosis in human plaque-derived vascular smooth muscle cells by Fas-ligand/Fas interactions,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 21, no. 9, pp. 1402–1407, 2001. View at Scopus
  7. A. Fernandez-Ortiz, J. J. Badimon, E. Falk et al., “Characterization of the relative thrombogenicity of atherosclerotic plaque components: implications for consequences of plaque rupture,” Journal of the American College of Cardiology, vol. 23, no. 7, pp. 1562–1569, 1994. View at Scopus
  8. P. Libby, Y. J. Geng, M. Aikawa et al., “Macrophages and atherosclerotic plaque stability,” Current Opinion in Lipidology, vol. 7, no. 5, pp. 330–335, 1996.
  9. E. Lutgens, E. D. De Muinck, P. J. E. H. M. Kitslaar, J. H. M. Tordoir, H. J. J. Wellens, and M. J. A. P. Daemen, “Biphasic pattern of cell turnover characterizes the progression from fatty streaks to ruptured human atherosclerotic plaques,” Cardiovascular Research, vol. 41, no. 2, pp. 473–479, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. A. B. Waqar, T. Koike, Y. Yu et al., “High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits,” Atherosclerosis, vol. 213, no. 1, pp. 148–155, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Liu, S. Kitajima, Y. Higaki et al., “High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits,” Metabolism, vol. 54, no. 1, pp. 132–138, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Koike, S. Kitajima, Y. Yu et al., “Human C-reactive protein does not promote atherosclerosis in transgenic rabbits,” Circulation, vol. 120, no. 21, pp. 2088–2094, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Zhang, H. Zheng, Q. Yu et al., “A practical method for quantifying atherosclerotic lesions in rabbits,” Journal of Comparative Pathology, vol. 142, no. 2-3, pp. 122–128, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Zhao, C. Zhang, Y. Lin et al., “The effects of rosiglitazone on aortic atherosclerosis of cholesterol-fed rabbits,” Thrombosis Research, vol. 123, no. 2, pp. 281–287, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. O. Tokunaga, J. Fan, and T. Watanabe, “Atherosclerosis- and age-related multinucleated variant endothelial cells in primary culture from human aorta,” American Journal of Pathology, vol. 135, no. 6, pp. 967–976, 1989. View at Scopus
  16. P. Cullen, R. Baetta, S. Bellosta et al., “Rupture of the atherosclerotic plaque: does a good animal model exist?” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 23, no. 4, pp. 535–542, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. P. H. E. Groot, B. J. M. Van Vlijmen, G. M. Benson et al., “Quantitative assessment of aortic atherosclerosis in APOE*3 leiden transgenic mice and its relationship to serum cholesterol exposure,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 16, no. 8, pp. 926–933, 1996. View at Scopus
  18. H. C. Stary, D. H. Blankenhorn, A. B. Chandler et al., “A definition of the intima of human arteries and of its atherosclerosis-prone regions: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation, vol. 85, no. 1, pp. 391–405, 1992. View at Scopus
  19. P. Libby and P. M. Ridker, “Inflammation and atherosclerosis: role of C-reactive protein in risk assessment,” American Journal of Medicine, vol. 116, no. 6, pp. 9–16, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Kleemann, L. Verschuren, M. J. Van Erk et al., “Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis,” Genome Biology, vol. 8, no. 9, article R200, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. V. Bobryshev, “Monocyte recruitment and foam cell formation in atherosclerosis,” Micron, vol. 37, no. 3, pp. 208–222, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. S. M. Schwartz, D. DeBlois, and E. R. M. O'Brien, “The intima: soil for atherosclerosis and restenosis,” Circulation Research, vol. 77, no. 3, pp. 445–465, 1995. View at Scopus
  23. H. C. Stary, A. B. Chandler, S. Glagov et al., “A definition of initial, fatty streak, and intermediate lesions of atherosclerosis: a report from the committee on vascular lesions of the council on arteriosclerosis, American Heart Association,” Circulation, vol. 89, no. 5, pp. 2462–2478, 1994. View at Scopus
  24. H. C. Stary, A. B. Chandler, R. E. Dinsmore et al., “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the council on arteriosclerosis, American heart association,” Circulation, vol. 92, no. 5, pp. 1355–1374, 1995. View at Scopus
  25. T. DeVries-Seimon, Y. Li, M. Y. Pin et al., “Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor,” Journal of Cell Biology, vol. 171, no. 1, pp. 61–73, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Lafont and P. Libby, “The smooth muscle cell: sinner or saint in restenosis and the acute coronary syndromes?” Journal of the American College of Cardiology, vol. 32, no. 1, pp. 283–285, 1998. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Shiomi, T. Ito, Y. Hirouchi, and M. Enomoto, “Fibromuscular cap composition is important for the stability of established atherosclerotic plaques in mature WHHL rabbits treated with statins,” Atherosclerosis, vol. 157, no. 1, pp. 75–84, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. A. J. Lusis, “Atherosclerosis,” Nature, vol. 407, no. 6801, pp. 233–241, 2000. View at Publisher · View at Google Scholar · View at Scopus