Table 2: Noncompartmental pharmacokinetic parameters obtained for cefuroxime lysine and cefuroxime sodium by using the WinNonlin analysis.

ParameterCefuroxime sodiumCefuroxime lysine
20 (mg/kg)40 (mg/kg)80 (mg/kg)20 (mg/kg)40 (mg/kg)80 (mg/kg)

𝜆 0.52 ± 0.180.63 ± 0.180.51 ± 0.260.53 ± 0.190.77 ± 0.080.57 ± 0.29
𝑡 1 / 2 (h)1.50 ± 0.631.21 ± 0.431.29 ± 0.391.46 ± 0.570.91 ± 0.111.09 ± 0.35
𝑉 (L/kg)0.66 ± 0.240.62 ± 0.330.60 ± 0.180.65 ± 0.280.41 ± 0.070.48 ± 0.13
CL (L/h/kg)0.31 ± 0.050.34 ± 0.060.32 ± 0.040.31 ± 0.030.31 ± 0.040.32 ± 0.07
MRT0-∞ (h)1.86 ± 0.781.54 ± 0.211.32 ± 0.121.85 ± 0.481.39 ± 0.121.43 ± 0.22
𝑇 m a x 0.63 ± 0.440.54 ± 0.100.46 ± 0.100.79 ± 0.600.50 ± 0.000.54 ± 0.10
𝐶 m a x (mg/L)41.05 ± 12.2884.20 ± 19.15186.9 ± 29.640.37 ± 15.892.46 ± 19.3175.7 ± 48.7
AUC0-∞ (mg·h/L)65.41 ± 11.7121.5 ± 23.8256.5 ± 33.666.04 ± 6.45130.9 ± 18.3259.3 ± 56.6
AUMC0-∞126.2 ± 77.1187.2 ± 41.2341.9 ± 71.1123.3 ± 36.1181.1 ± 23.3371.9 ± 98.6
𝐶 a d j u s t e d 2.05 ± 0.612.10 ± 0.482.34 ± 0.372.02 ± 0.792.31 ± 0.482.20 ± 0.61
AUCadjusted3.27 ± 0.583.04 ± 0.593.21 ± 0.423.30 ± 0.183.27 ± 0.463.24 ± 0.71

The denotations are 𝜆 : elimination rate constant; 𝑡 1 / 2 : the drug elimination half-life; 𝑉 : volume of distribution; CL: clearance; MRT0-∞: mean residence time from time zero to infinity; 𝑇 m a x : time to reach peak concentration; 𝐶 m a x : peak concentration, AUC0-∞: the area under the plasma concentration-time curve from time zero to infinity; AUMC0-∞: area under the first moment curve from time zero to infinity; 𝐶 a d j u s t e d : 𝐶 m a x adjusted by dose; AUCadjusted: AUC0-∞  adjusted by dose; the values are expressed by mean ± SD, where 𝑛 = 6 .