Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs

Table 2

Noncompartmental pharmacokinetic parameters obtained for cefuroxime lysine and cefuroxime sodium by using the WinNonlin analysis.

Parameter	Cefuroxime sodium			Cefuroxime lysine
	20 (mg/kg)	40 (mg/kg)	80 (mg/kg)	20 (mg/kg)	40 (mg/kg)	80 (mg/kg)
𝜆	0.52 ± 0.18	0.63 ± 0.18	0.51 ± 0.26	0.53 ± 0.19	0.77 ± 0.08	0.57 ± 0.29
𝑡1/2 (h)	1.50 ± 0.63	1.21 ± 0.43	1.29 ± 0.39	1.46 ± 0.57	0.91 ± 0.11	1.09 ± 0.35
𝑉 (L/kg)	0.66 ± 0.24	0.62 ± 0.33	0.60 ± 0.18	0.65 ± 0.28	0.41 ± 0.07	0.48 ± 0.13
CL (L/h/kg)	0.31 ± 0.05	0.34 ± 0.06	0.32 ± 0.04	0.31 ± 0.03	0.31 ± 0.04	0.32 ± 0.07
MRT0-∞ (h)	1.86 ± 0.78	1.54 ± 0.21	1.32 ± 0.12	1.85 ± 0.48	1.39 ± 0.12	1.43 ± 0.22
𝑇max	0.63 ± 0.44	0.54 ± 0.10	0.46 ± 0.10	0.79 ± 0.60	0.50 ± 0.00	0.54 ± 0.10
𝐶max (mg/L)	41.05 ± 12.28	84.20 ± 19.15	186.9 ± 29.6	40.37 ± 15.8	92.46 ± 19.3	175.7 ± 48.7
AUC0-∞ (mg·h/L)	65.41 ± 11.7	121.5 ± 23.8	256.5 ± 33.6	66.04 ± 6.45	130.9 ± 18.3	259.3 ± 56.6
AUMC0-∞	126.2 ± 77.1	187.2 ± 41.2	341.9 ± 71.1	123.3 ± 36.1	181.1 ± 23.3	371.9 ± 98.6
𝐶adjusted	2.05 ± 0.61	2.10 ± 0.48	2.34 ± 0.37	2.02 ± 0.79	2.31 ± 0.48	2.20 ± 0.61
AUCadjusted	3.27 ± 0.58	3.04 ± 0.59	3.21 ± 0.42	3.30 ± 0.18	3.27 ± 0.46	3.24 ± 0.71

The denotations are 𝜆: elimination rate constant; 𝑡_1/2: the drug elimination half-life; 𝑉: volume of distribution; CL: clearance; MRT_0-∞: mean residence time from time zero to infinity; 𝑇_max: time to reach peak concentration; 𝐶_max: peak concentration, AUC_0-∞: the area under the plasma concentration-time curve from time zero to infinity; AUMC_0-∞: area under the first moment curve from time zero to infinity; 𝐶_adjusted: 𝐶_max adjusted by dose; AUC_adjusted: AUC_0-∞  adjusted by dose; the values are expressed by mean ± SD, where 𝑛=6.