Table 3: Noncompartmental pharmacokinetic parameters obtained for cefuroxime lysine and cefuroxime sodium by using DAS analysis.

ParameterCefuroxime sodiumCefuroxime lysine
20 (mg/kg)40 (mg/kg)80 (mg/kg)20 (mg/kg)40 (mg/kg)80 (mg/kg)

𝜆 0.56 ± 0.090.72 ± 0.160.50 ± 0.300.62 ± 0.130.80 ± 0.170.77 ± 0.30
𝑡 1 / 2 (h)1.27 ± 0.211.01 ± 0.231.48 ± 0.861.15 ± 0.200.90 ± 0.210.98 ± 0.28
𝑉 (L/kg)0.58 ± 0.140.46 ± 0.120.63 ± 0.310.51 ± 0.080.41 ± 0.110.42 ± 0.07
CL (L/h/kg)0.31 ± 0.050.34 ± 0.060.32 ± 0.040.31 ± 0.020.31 ± 0.040.32 ± 0.07
MRT (h)1.83 ± 0.791.54 ± 0.211.32 ± 0.112.11 ± 0.621.38 ± 0.131.42 ± 0.20
𝑇 m a x 0.63 ± 0.440.54 ± 0.100.46 ± 0.100.79 ± 0.600.50 ± 0.000.54 ± 0.10
𝐶 m a x (mg/L)41.05 ± 12.2884.20 ± 19.15186.9 ± 29.640.37 ± 15.892.46 ± 19.3175.7 ± 48.7
AUC0-∞ (mg·h/L)65.35 ± 11.7121.6 ± 23.5256.5 ± 33.465.63 ± 3.61130.8 ± 18.3259.2 ± 56.6
AUMC0-∞124.3 ± 75.7187.8 ± 39.2340.4 ± 67.1138.4 ± 40.1180.1 ± 23.6369.7 ± 98.6
𝐶 a d j u s t e d 2.05 ± 0.612.10 ± 0.482.34 ± 0.372.02 ± 0.792.31 ± 0.482.20 ± 0.61
AUCadjusted3.27 ± 0.583.04 ± 0.593.21 ± 0.423.28 ± 0.183.27 ± 0.463.24 ± 0.71

The denotations are 𝜆 : elimination rate constant; 𝑡 1 / 2 : the drug elimination half life; 𝑉 : volume of distribution; CL: clearance; MRT0-∞: mean residence time from time zero to infinity; 𝑇 m a x : time to reach peak concentration; 𝐶 m a x : peak concentration; AUC0-∞: the area under the plasma concentration-time curve from time zero to infinity; AUMC0-∞: area under the first moment curve from time zero to infinity; 𝐶 a d j u s t e d : 𝐶 m a x adjusted by dose; AUCadjusted: AUC0-∞  adjusted by dose; the values are expressed by mean ± SD, where 𝑛 = 6 .