Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs

Table 3

Noncompartmental pharmacokinetic parameters obtained for cefuroxime lysine and cefuroxime sodium by using DAS analysis.

Parameter	Cefuroxime sodium			Cefuroxime lysine
	20 (mg/kg)	40 (mg/kg)	80 (mg/kg)	20 (mg/kg)	40 (mg/kg)	80 (mg/kg)
𝜆	0.56 ± 0.09	0.72 ± 0.16	0.50 ± 0.30	0.62 ± 0.13	0.80 ± 0.17	0.77 ± 0.30
𝑡1/2 (h)	1.27 ± 0.21	1.01 ± 0.23	1.48 ± 0.86	1.15 ± 0.20	0.90 ± 0.21	0.98 ± 0.28
𝑉 (L/kg)	0.58 ± 0.14	0.46 ± 0.12	0.63 ± 0.31	0.51 ± 0.08	0.41 ± 0.11	0.42 ± 0.07
CL (L/h/kg)	0.31 ± 0.05	0.34 ± 0.06	0.32 ± 0.04	0.31 ± 0.02	0.31 ± 0.04	0.32 ± 0.07
MRT (h)	1.83 ± 0.79	1.54 ± 0.21	1.32 ± 0.11	2.11 ± 0.62	1.38 ± 0.13	1.42 ± 0.20
𝑇max	0.63 ± 0.44	0.54 ± 0.10	0.46 ± 0.10	0.79 ± 0.60	0.50 ± 0.00	0.54 ± 0.10
𝐶max (mg/L)	41.05 ± 12.28	84.20 ± 19.15	186.9 ± 29.6	40.37 ± 15.8	92.46 ± 19.3	175.7 ± 48.7
AUC0-∞ (mg·h/L)	65.35 ± 11.7	121.6 ± 23.5	256.5 ± 33.4	65.63 ± 3.61	130.8 ± 18.3	259.2 ± 56.6
AUMC0-∞	124.3 ± 75.7	187.8 ± 39.2	340.4 ± 67.1	138.4 ± 40.1	180.1 ± 23.6	369.7 ± 98.6
𝐶adjusted	2.05 ± 0.61	2.10 ± 0.48	2.34 ± 0.37	2.02 ± 0.79	2.31 ± 0.48	2.20 ± 0.61
AUCadjusted	3.27 ± 0.58	3.04 ± 0.59	3.21 ± 0.42	3.28 ± 0.18	3.27 ± 0.46	3.24 ± 0.71

The denotations are 𝜆: elimination rate constant; 𝑡_1/2: the drug elimination half life; 𝑉: volume of distribution; CL: clearance; MRT_0-∞: mean residence time from time zero to infinity; 𝑇_max: time to reach peak concentration; 𝐶_max: peak concentration; AUC_0-∞: the area under the plasma concentration-time curve from time zero to infinity; AUMC_0-∞: area under the first moment curve from time zero to infinity; 𝐶_adjusted: 𝐶_max adjusted by dose; AUC_adjusted: AUC_0-∞  adjusted by dose; the values are expressed by mean ± SD, where 𝑛=6.