Table 5: Population pharmacokinetic parameter estimates of cefuroxime lysine and cefuroxime sodium in dog plasma after intravenous infusion in 30 min (20, 40, 80 mg/kg) obtained by 3-compartment pharmacokinetic model.

ParameterCefuroxime lysineCefuroxime sodium
ValueRSE (%) 𝜎 ValueRSE (%) 𝜎

Cl (mL/h)3.7413.50.0354.1018.20.0173
𝑉 1 (mL)1.706.30.8811.0019.10.626
𝑄 2 (mL/min)29.53.51.7738.525.70.47
𝑉 2 (mL)3.5814.24.199.50.0056
𝑄 3 (mL/min)0.30826.40.058729.1
𝑉 3 (mL)15822.113.627.60.0029

Residual variability
𝜎 1 0.050122.4 (CV%)0.068626.2 (CV%)
𝜎 2 0.00290.0541 (SD)0.00380.0619 (SD)

The denotations are RSE (%): relative standard error; 𝜎 : residual variability; 𝑉 1 : central volume of distribution; 𝑉 2 , 𝑉 3 : two peripheral volumes of distribution; 𝑄 2 , 𝑄 3 : intercompartmental clearances.