Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs

Table 5

Population pharmacokinetic parameter estimates of cefuroxime lysine and cefuroxime sodium in dog plasma after intravenous infusion in 30 min (20, 40, 80 mg/kg) obtained by 3-compartment pharmacokinetic model.

Parameter	Cefuroxime lysine			Cefuroxime sodium
	Value	RSE (%)	𝜎	Value	RSE (%)	𝜎
Cl (mL/h)	3.74	13.5	0.035	4.10	18.2	0.0173
𝑉1 (mL)	1.70	6.3	0.881	1.00	19.1	0.626
𝑄2 (mL/min)	29.5	3.5	1.77	38.5	25.7	0.47
𝑉2 (mL)	3.58	14.2	—	4.19	9.5	0.0056
𝑄3 (mL/min)	0.308	26.4	—	0.0587	29.1	—
𝑉3 (mL)	158	22.1	—	13.6	27.6	0.0029
Residual variability
𝜎1	0.0501	22.4 (CV%)		0.0686	26.2 (CV%)
𝜎2	0.0029	0.0541 (SD)		0.0038	0.0619 (SD)

The denotations are RSE (%): relative standard error; 𝜎: residual variability; 𝑉₁: central volume of distribution; 𝑉₂, 𝑉₃: two peripheral volumes of distribution; 𝑄₂, 𝑄₃: intercompartmental clearances.