Table 5: Antinociceptive effect of the carotenoid extract from guajillo pepper using a hot plate test on mice.

TreatmentDose (mg/kg)Latency of response time (s)
Before treatmentAfter treatment
0 min30 min60 min120 min180 min240 min300 min360 min

Control05 ± 0.47 ± 0.48 ± 17 ± 19 ± 18 ± 19 ± 18 ± 1
Indomethacin75 ± 112 ± 2a12 ± 1a12 ± 1a14 ± 2a13 ± 1a13 ± 212 ± 2
Carotenoids extracted
from guajillo pepper
55 ± 0.29 ± 19 ± 18 ± 111 ± 210 ± 212 ± 110 ± 1
205 ± 16 ± 17 ± 110 ± 19 ± 111 ± 110 ± 112 ± 3
805 ± 19 ± 210 ± 2a15 ± 4a15 ± 3a15 ± 3a18 ± 3a18 ± 4a

Results are expressed as mean ± S.E.M ( 𝑛 = 6 ) of response time (s). aStatistical significance with respect to the control was calculated by one-way ANOVA followed by Dunnett’s test ( 𝑃 0 . 0 5 ). Isotonic saline solution was used as the control and indomethacin was used as the reference treatment.