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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 534384, 7 pages
http://dx.doi.org/10.1155/2012/534384
Research Article

Cigarette Smoke Extract Stimulates Rat Pulmonary Artery Smooth Muscle Cell Proliferation via PKC-PDGFB Signaling

1Department of Respiration Medicine, First Hospital, Shanxi Medical University, Taiyuan 030001, China
2Department of Respiration Medicine, The People’s Hospital of Shanxi Province, Taiyuan 030012, China

Received 16 February 2012; Revised 17 April 2012; Accepted 23 April 2012

Academic Editor: Leon Spicer

Copyright © 2012 Ai-ping Xing et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Mandegar, Y. C. B. Fung, W. Huang, C. V. Remillard, L. J. Rubin, and J. X. J. Yuan, “Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension,” Microvascular Research, vol. 68, no. 2, pp. 75–103, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. G. P. Pidgeon, R. Tamosiuniene, G. Chen et al., “Intravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by cyclooxygenase-2,” Circulation, vol. 110, no. 17, pp. 2701–2707, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. J. A. Barberà, V. I. Peinado, and S. Santos, “Pulmonary hypertension in chronic obstructive pulmonary disease,” European Respiratory Journal, vol. 21, no. 5, pp. 892–905, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. J. L. Wright, R. D. Levy, and A. Churg, “Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment,” Thorax, vol. 60, no. 7, pp. 605–609, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. V. I. Peinado, S. Pizarro, and J. A. Barberà, “Pulmonary vascular involvement in COPD,” Chest, vol. 134, no. 4, pp. 808–814, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Jawien, D. F. Bowen-Pope, V. Lindner, S. M. Schwartz, and A. W. Clowes, “Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty,” Journal of Clinical Investigation, vol. 89, no. 2, pp. 507–511, 1992. View at Scopus
  7. A. Sachinidis, R. Locher, J. Hoppe, and W. Vetter, “The platelet-derived growth factor isomers, PDGF-AA, PDGF-AB and PDGF-BB, induce contraction of vascular smooth muscle cells by different intracellular mechanisms,” FEBS Letters, vol. 275, no. 1-2, pp. 95–98, 1990. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Sakao, K. Tatsumi, and N. F. Voelkel, “Reversible or irreversible remodeling in pulmonary arterial hypertension,” American Journal of Respiratory Cell and Molecular Biology, vol. 43, no. 6, pp. 629–634, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Humbert, G. Monti, M. Fartoukh et al., “Platelet-derived growth factor expression in primary pulmonary hypertension: comparison of HIV seropositive and HIV seronegative patients,” European Respiratory Journal, vol. 11, no. 3, pp. 554–559, 1998. View at Scopus
  10. V. Balasubramaniam, T. D. Le Cras, D. D. Ivy, T. R. Grover, J. P. Kinsella, and S. H. Abman, “Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus,” American Journal of Physiology, vol. 284, no. 5, pp. L826–L833, 2003. View at Scopus
  11. R. T. Schermuly, E. Dony, H. A. Ghofrani et al., “Reversal of experimental pulmonary hypertension by PDGF inhibition,” Journal of Clinical Investigation, vol. 115, no. 10, pp. 2811–2821, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Yamamoto, M. Acevedo-Duncan, C. E. Chalfant, N. A. Patel, J. E. Watson, and D. R. Cooper, “The roles of protein kinase C βI and βII in vascular smooth muscle cell proliferation,” Experimental Cell Research, vol. 240, no. 2, pp. 349–358, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. P. F. Li, C. Maasch, H. Haller, R. Dietz, and R. von Harsdorf, “Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells,” Circulation, vol. 100, no. 9, pp. 967–973, 1999. View at Scopus
  14. H. Haller, C. Lindschau, P. Quass, A. Distler, and F. C. Luft, “Differentiation of vascular smooth muscle cells and the regulation of protein kinase C-α,” Circulation Research, vol. 76, no. 1, pp. 21–29, 1995. View at Scopus
  15. V. K. Kalra, Y. Ying, K. Deemer, R. Natarajan, J. L. Nadler, and T. D. Coates, “Mechanism of cigarette smoke condensate induced adhesion of human monocytes to cultured endothelial cells,” Journal of Cellular Physiology, vol. 160, no. 1, pp. 154–162, 1994. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Kashyap, A. A. Floreani, A. J. Heires, S. D. Sanderson, and T. A. Wyatt, “Protein kinase c-α mediates cigarette smoke extract- and complement factor 5a-stimulated interleukin-8 release in human bronchial epithelial cells,” Journal of Investigative Medicine, vol. 50, no. 1, pp. 46–53, 2002. View at Scopus
  17. S. D. Lee, D. S. Lee, Y. G. Chun et al., “Cigarette smoke extract induces endothelin-1 via protein kinase C in pulmonary artery endothelial cells,” American Journal of Physiology, vol. 281, no. 2, pp. L403–L411, 2001. View at Scopus
  18. D. Leszczynski, S. Joenväärä, and M. L. Foegh, “Protein kinase C-α regulates proliferation but not apoptosis in rat coronary vascular smooth muscle cells,” Life Sciences, vol. 58, no. 7, pp. 599–606, 1996. View at Publisher · View at Google Scholar · View at Scopus
  19. U. Oltmanns, K. F. Chung, M. Walters, M. John, and J. A. Mitchell, “Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle,” Respiratory Research, vol. 6, pp. 10–19, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. S. D. Shapira, “Smoke gets in your cells,” American Journal of Respiratory Cell and Molecular Biology, vol. 31, no. 5, pp. 481–484, 2004.
  21. G. G. Pietra, F. Capron, S. Stewart, et al., “Pathologic assessment of vasculopathies in pulmonary hypertension,” Journal of the American College of Cardiology, vol. 43, no. 12, pp. 25S–32S, 2004.
  22. M. Rabinovitch, “The mouse through the looking glass: a new door into the pathophysiology of pulmonary hypertension,” Circulation Research, vol. 94, no. 8, pp. 1001–1004, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Luppi, J. Aarbiou, S. van Wetering et al., “Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione,” Respiratory Research, vol. 6, pp. 140–151, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Ambalavanan, W. F. Carlo, A. Bulger, J. Shi, and J. B. Philips, “Effect of cigarette smoke extract on neonatal porcine vascular smooth muscle cells,” Toxicology and Applied Pharmacology, vol. 170, no. 2, pp. 130–136, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. C. H. Heldin and B. Westermark, “Mechanism of action and in vivo role of platelet-derived growth factor,” Physiological Reviews, vol. 79, no. 4, pp. 1283–1316, 1999. View at Scopus
  26. L. J. Reigstad, J. E. Varhaug, and J. R. Lillehaug, “Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family,” The FEBS Journal, vol. 272, no. 22, pp. 5723–5741, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Yahiaoui, A. Villeneuve, H. Valderrama-Carvajal, F. Burke, and E. D. Fixman, “Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells,” Cellular Physiology and Biochemistry, vol. 17, no. 1-2, pp. 37–46, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. D. X. F. Deng, J. M. Spin, A. Tsalenko et al., “Molecular signatures determining coronary artery and saphenous vein smooth muscle cell phenotypes: distinct responses to stimuli,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 5, pp. 1058–1065, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. M. E. Barnett, D. K. Madgwick, and D. J. Takemoto, “Protein kinase C as a stress sensor,” Cellular Signalling, vol. 19, no. 9, pp. 1820–1829, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. E. C. Dempsey, C. D. Cool, and C. M. Littler, “Lung disease and PKCs,” Pharmacological Research, vol. 55, no. 6, pp. 545–559, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. J. W. Assenderab, E. Kontny, and B. Bertil, “Expression of protein kinase C isoforms in smooth muscle cells in various states of differentiation,” FEBS Letters, vol. 55, no. 1, pp. 76–80, 1994.
  32. D. Leszczynski, S. Joenväärä, and M. L. Foegh, “Protein kinase C-α regulates proliferation but not apoptosis in rat coronary vascular smooth muscle cells,” Life Sciences, vol. 58, no. 7, pp. 599–606, 1996. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Sasaguri, C. Kosaka, K. Zen, J. Masuda, K. Shimokado, and J. Ogata, “Protein kinase C isoforms that may mediate G1/S inhibition in cultured vascular smooth muscle cells,” Annals of the New York Academy of Sciences, vol. 748, pp. 590–591, 1995. View at Scopus
  34. L. Pukac, J. Huangpu, and M. J. Karnovsky, “Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration,” Experimental Cell Research, vol. 242, no. 2, pp. 548–560, 1998. View at Publisher · View at Google Scholar · View at Scopus