Comprehensive Evaluation of Different T-Helper Cell Subsets Differentiation and Function in Rheumatoid Arthritis
Table 3
Th cell-related cytokine changes of RA patients with different DAS28 scores.
Cytokine
Low DAS28 ()
Moderate DAS28 ()
High DAS28 ()
Control ()
TGF-β
158.6 ± 6.4
157.4 ± 13.0
159.8 ± 11.9
156.0 ± 6.4
2.9
0.404
IL-17A
36.4 ± 17.8
44.0 ± 12.7*
51.4 ± 23.1*
32.5 ± 7.1
19.6
<0.001
IFN-γ
3.3 ± 0.4
4.7 ± 2.2
5.7 ± 3.7*
3.6 ± 0.7
16.4
0.001
TNF-α
4.8 ± 2.9*
4.1 ± 3.1
4.9 ± 5.6*
3.5 ± 0.8
16.6
0.001
IL-10
5.9 ± 2.0
6.8 ± 4.3*
7.4 ± 4.3*
5.1 ± 2.3
17.9
<0.001
IL-6
9.5 ± 53.5
29.7 ± 57.4*
12.8 ± 43.4*
6.8 ± 3.2
27.8
<0.001
IL-4
13.1 ± 2.0*
13.8 ± 6.9
14.8 ± 4.8*
10.9 ± 2.0
20.3
<0.001
IL-2
12.5 ± 2.5*
13.0 ± 4.6*
14.3 ± 5.1*
11.1 ± 1.4
23.8
<0.001
Values are expressed as median ± interquartile range; the differences between different DAS28 RA groups were determined by Kruskal-Wallis test; *P values less than 0.001 were considered significant.
