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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 536761, 12 pages
http://dx.doi.org/10.1155/2012/536761
Review Article

How Do Cytokines Trigger Genomic Instability?

1Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
22nd Department of Propedeutic Surgery, Laikon General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
3Department of Anatomy, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
4Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 11635 Athens, Greece

Received 25 January 2012; Accepted 8 April 2012

Academic Editor: Vassilis Gorgoulis

Copyright © 2012 Ioannis L. Aivaliotis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Inflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in the interaction between the cells of tumor microenvironment. A comprehensive study of the role of cytokines in the context of the inflammation-tumorigenesis interplay helps us to shed light in the pathogenesis of cancer. In this paper we focus on the role of cytokines in the development of genomic instability, an evolving hallmark of cancer.