541245.fig.001a
(a)
541245.fig.001b
(b)
Figure 1: Schematic representation of AE DNA constructs. High-level transcription is driven by the human EF1 𝛼 promoter. Protein-coding elements include the N-terminal mitochondrial transport signal of human cytochrome oxidase VIII, nuclear-coded wild-type (a) or mutant (b) mouse Atp6 gene sequence and a C-terminal myc epitope tag.