Nuclear Expression of a Mitochondrial DNA Gene: Mitochondrial Targeting of Allotopically Expressed Mutant ATP6 in Transgenic Mice
Figure 1
Schematic representation of AE DNA constructs. High-level transcription is driven by the human EF1 promoter. Protein-coding elements include the N-terminal mitochondrial transport signal of human cytochrome oxidase VIII, nuclear-coded wild-type (a) or mutant (b) mouse Atp6 gene sequence and a C-terminal myc epitope tag.
