Table 1: The incidence of liver tumors induced by DEN/PB in mice and the effect of bicyclol determined by H&E staining and histological evaluation.

GroupDosage
(mg/kg)
HCCHepatomaCholangioadenomaCapillary
hemangioma
MBCA

Control0.0 (0/6)0.0 (0/6)0.0 (0/6)0.0 (0/6)0.0 (0/6)
DEN/PB33.3 (3/9)55.6 (5/9)22.2(2/9)11.1 (1/9)88.9 (8/9)
Bicyclol10011.1 (1/9)22.2 (2/9)11.1(1/9)0.0 (0/9)33.3 (3/9)
2000.0 (0/8)0.0 (0/8)0.0 (0/8)0.0 (0/8)50.0 (4/8)

HCC: hepatocellular carcinoma; MBCA: multiple bile canaliculi hyperplasia.