Table 3: Genes exhibiting differential expression between risk and nonrisk cells in the canonical pathways identified through ingenuity pathway analysis. Fold up/down column is positive in the case that the gene expression is higher in the risk haplotype cells, and negative in the case that gene expression is higher in the nonrisk cells. PIK3CA: phosphoinositide-3-kinase, catalytic, alpha; RAC1: Ras-related C3 botulinum toxin substrate 1. *The IFNB1 gene is found in both the interferon and Toll-like receptor pathways.

Gene pathway Gene symbolMock infected 16 hoursEBV live virus infected 16 hours
Avg. nonriskAvg. riskRatioFold up/downAvg. nonriskAvg. riskRatioFold up/down

InterferonIFNB1*104.953.890.04−26.995.399.151.701.70
STAT171.0852.840.74−1.35184.29244.121.321.32
OAS156.0484.551.511.5149.87107.782.162.16
MX13179.145161.021.621.623409.356199.201.821.82
IFNAR2959.141637.111.711.711437.471094.970.76−1.31
IFITM1439.88944.412.152.152128.612602.681.221.22

Toll-like receptorIFNB1*104.953.890.04−26.995.399.151.701.70
FOS116.4853.840.46−2.1690.05120.601.341.34
MYD88281.53152.570.54−1.85181.06226.621.251.25
TNFAIP3439.96321.290.73−1.37728.35377.230.52−1.93
TLR126.5046.761.761.7667.59116.371.721.72
LY96 (MD-2)560.791274.322.272.271128.471208.541.071.07
CD14401.171272.533.173.17139.53450.093.233.23

B-Cell receptorCD79B2222.90991.480.45−2.24797.14827.441.041.04
CD79A41.3219.080.46−2.176526.625973.720.92−1.09
RAC11407.29930.840.66−1.514.362.640.61−1.65
MAPK9105.8771.020.67−1.4962.5080.351.291.29
AKT1512.79353.650.69−1.4513.026.740.52−1.93
NFKB26.444.850.75−1.33495.75147.180.30−3.37
PIK3CA25.8640.051.551.5579.9649.710.62−1.61
NFAT5123.74222.631.801.805.142.700.52−1.91
GSK3B68.58123.651.801.80177.2391.070.51−1.95