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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 596870, 9 pages
http://dx.doi.org/10.1155/2012/596870
Review Article

The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening

Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, 188 Shizi Road, Jiangsu, Suzhou 215006, China

Received 31 July 2012; Revised 2 October 2012; Accepted 3 October 2012

Academic Editor: Mouldy Sioud

Copyright © 2012 Qiaoli Gu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Farber, R. Chin, Y. Song, P. Huie, and S. Goodman, “Chronic antigen-specific immune-system activation may potentially be involved in the loosening of cemented acetabular components,” Journal of Biomedical Materials Research, vol. 55, no. 3, pp. 433–441, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Koulouvaris, K. Ly, L. B. Ivashkiv et al., “Expression profiling reveals alternative macrophage activation and impaired osteogenesis in periprosthetic osteolysis,” Journal of Orthopaedic Research, vol. 26, no. 1, pp. 106–116, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Chiu, M. Ting, R. L. Smith, and S. B. Goodman, “Ultrahigh molecular weight polyethylene wear debris inhibits osteoprogenitor proliferation and differentiation in vitro,” Journal of Biomedical Materials Research Part A, vol. 89, no. 1, pp. 242–247, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Kurtz, K. Ong, E. Lau, F. Mowat, and M. Halpern, “Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030,” Journal of Bone and Joint Surgery Series A, vol. 89, no. 4, pp. 780–785, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Herberts and H. Malchau, “Long-term registration has improved the quality of hip replacement: a review of the Swedish THR Register comparing 160,000 cases,” Acta Orthopaedica Scandinavica, vol. 71, no. 2, pp. 111–121, 2000. View at Scopus
  6. O. Robertsson, K. Knutson, S. Lewold, and L. Lidgren, “The Swedish Knee Arthroplasty Register 1975–1997: an update with special emphasis on 41,223 knees operated on in 1988–1997,” Acta Orthopaedica Scandinavica, vol. 72, no. 5, pp. 503–513, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. E. Ingham and J. Fisher, “The role of macrophages in osteolysis of total joint replacement,” Biomaterials, vol. 26, no. 11, pp. 1271–1286, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Goodman, P. Aspenberg, Y. Song et al., “Tissue ingrowth and differentiation in the bone-harvest chamber in the presence of cobalt-chromium-alloy and high-density-polyethylene particles,” Journal of Bone and Joint Surgery Series A, vol. 77, no. 7, pp. 1025–1035, 1995. View at Scopus
  9. W. J. Maloney and R. L. Smith, “Periprosthetic osteolysis in total hip arthroplasty: the role of particulate wear debris,” Instructional Course Lectures, vol. 45, pp. 171–182, 1996. View at Scopus
  10. A. J. Rao, E. Gibon, T. Ma, Z. Yao, R. L. Smith, and S. B. Goodman, “Revision joint replacement, wear particles, and macrophage polarization,” Acta Biomaterialia, vol. 8, no. 7, pp. 2815–2823, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. J. D. Witt and M. Swann, “Metal wear and tissue response in failed titanium alloy total hip replacements,” Journal of Bone and Joint Surgery Series B, vol. 73, no. 4, pp. 559–563, 1991. View at Scopus
  12. P. H. Wooley and E. M. Schwarz, “Aseptic loosening,” Gene Therapy, vol. 11, no. 4, pp. 402–407, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. P. E. Purdue, “Alternative macrophage activation in periprosthetic osteolysis,” Autoimmunity, vol. 41, no. 3, pp. 212–217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Miyanishi, M. C. D. Trindade, T. Ma, S. B. Goodman, D. J. Schurman, and R. L. Smith, “Periprosthetic osteolysis: induction of vascular endothelial growth factor from human monocyte/macrophages by orthopaedic biomaterial particles,” Journal of Bone and Mineral Research, vol. 18, no. 9, pp. 1573–1583, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. P. E. Purdue, P. Koulouvaris, B. J. Nestor, and T. P. Sculco, “The central role of wear debris in periprosthetic osteolysis,” HSS Journal, vol. 2, no. 2, pp. 102–113, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. S. M. Horowitz and J. B. Gonzales, “Inflammatory response to implant particulates in a macrophage/osteoblast coculture model,” Calcified Tissue International, vol. 59, no. 5, pp. 392–396, 1996. View at Publisher · View at Google Scholar · View at Scopus
  17. C. A. St Pierre, M. Chan, Y. Iwakura, D. C. Ayers, E. A. Kurt-Jones, and R. W. Finberg, “Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles,” Journal of Orthopaedic Research, vol. 28, no. 11, pp. 1418–1424, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. R. T. Beck, K. D. Illingworth, and K. J. Saleh, “Review of periprosthetic osteolysis in total joint arthroplasty: an emphasis on host factors and future directions,” Journal of Orthopaedic Research, vol. 30, no. 4, pp. 541–546, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. T. W. Bauer, “Particles and periimplant bone resorption,” Clinical Orthopaedics and Related Research, no. 405, pp. 138–143, 2002. View at Scopus
  20. T. Koreny, M. Tunyogi-Csapó, I. Gál, C. Vermes, J. J. Jacobs, and T. T. Glant, “The role of fibroblasts and fibroblast-derived factors in periprosthetic osteolysis,” Arthritis and Rheumatism, vol. 54, no. 10, pp. 3221–3232, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. D. P. Pioletti and A. Kottelat, “The influence of wear particles in the expression of osteoclastogenesis factors by osteoblasts,” Biomaterials, vol. 25, no. 27, pp. 5803–5808, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. C. C. Okafor, H. Haleem-Smith, P. Laqueriere, P. A. Manner, and R. S. Tuan, “Particulate endocytosis mediates biological responses of human mesenchymal stem cells to titanium wear debris,” Journal of Orthopaedic Research, vol. 24, no. 3, pp. 461–473, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. M. L. Wang, L. J. Nesti, R. Tuli et al., “Titanium particles suppress expression of osteoblastic phenotype in human mesenchymal stem cells,” Journal of Orthopaedic Research, vol. 20, no. 6, pp. 1175–1184, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Haleem-Smith, E. Argintar, C. Bush et al., “Biological responses of human mesenchymal stem cells to titanium wear debris particles,” Journal of Orthopaedic Research, vol. 30, no. 6, pp. 853–863, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Takagi, Y. Tamaki, H. Hasegawa et al., “Toll-like receptors in the interface membrane around loosening total hip replacement implants,” Journal of Biomedical Materials Research Part A, vol. 81, no. 4, pp. 1017–1026, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Hirayama, Y. Tamaki, Y. Takakubo et al., “Toll-like receptors and their adaptors are regulated in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles,” Journal of Orthopaedic Research, vol. 29, no. 7, pp. 984–992, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. J. I. Pearl, T. Ma, A. R. Irani et al., “Role of the Toll-like receptor pathway in the recognition of orthopedic implant wear-debris particles,” Biomaterials, vol. 32, no. 24, pp. 5535–5542, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Lassus, V. Waris, J. W. Xu et al., “Increased interleukin-8 (IL-8) expression is related to aseptic loosening of total hip replacement,” Archives of Orthopaedic and Trauma Surgery, vol. 120, no. 5-6, pp. 328–332, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. X. Mao, X. Pan, X. Peng, T. Cheng, and X. Zhang, “Inhibition of titanium particle-induced inflammation by the proteasome inhibitor bortezomib in murine macrophage-like RAW 264.7 cells,” Inflammation, vol. 35, no. 4, pp. 1411–1418, 2012.
  30. M. Takagi, “Toll-like receptor—a potent driving force behind rheumatoid arthritis,” Journal of Clinical and Experimental Hematopathology, vol. 51, no. 2, pp. 77–92, 2011.
  31. B. Lemaitre, E. Nicolas, L. Michaut, J. M. Reichhart, and J. A. Hoffmann, “The dorsoventral regulatory gene cassette spatzle/Toll/Cactus controls the potent antifungal response in Drosophila adults,” Cell, vol. 86, no. 6, pp. 973–983, 1996. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Pasare and R. Medzhitov, “Toll-like receptors: linking innate and adaptive immunity,” Microbes and Infection, vol. 6, no. 15, pp. 1382–1387, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. R. M. Pope and Q. Q. Huang, “The role of Toll-like receptors in rheumatoid arthritis,” Current Rheumatology Reports, vol. 11, no. 5, pp. 357–364, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Akira and K. Takeda, “Toll-like receptor signalling,” Nature Reviews Immunology, vol. 4, no. 7, pp. 499–511, 2004. View at Scopus
  35. K. Takeda and S. Akira, “Toll-like receptors in innate immunity,” International Immunology, vol. 17, no. 1, pp. 1–14, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Y. Chen and G. Nuñez, “Sterile inflammation: sensing and reacting to damage,” Nature Reviews Immunology, vol. 10, no. 12, pp. 826–837, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. T. Kondo, T. Kawai, and S. Akira, “Dissecting negative regulation of Toll-like receptor signaling,” Trends in Immunology, vol. 33, no. 9, pp. 449–458, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. J. Pajarinen, E. Cenni, L. Savarino et al., “Profile of toll-like receptor-positive cells in septic and aseptic loosening of total hip arthroplasty implants,” Journal of Biomedical Materials Research Part A, vol. 94, no. 1, pp. 84–92, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. T. Lähdeoja, J. Pajarinen, V. P. Kouri, T. Sillat, J. Salo, and Y. T. Konttinen, “Toll-like receptors and aseptic loosening of hip endoprosthesis—a potential to respond against danger signals?” Journal of Orthopaedic Research, vol. 28, no. 2, pp. 184–190, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. H. N. Hao, B. Zheng, S. Nasser et al., “The roles of monocytic heat shock protein 60 and Toll-like receptors in the regional inflammation response to wear debris particles,” Journal of Biomedical Materials Research Part A, vol. 92, no. 4, pp. 1373–1381, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. E. M. Greenfield, M. A. Beidelschies, J. M. Tatro, V. M. Goldberg, and A. G. Hise, “Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate toll-like receptors,” The Journal of Biological Chemistry, vol. 285, no. 42, pp. 32378–32384, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. J. Pajarinen, Z. Mackiewicz, R. Pöllänen et al., “Titanium particles modulate expression of Toll-like receptor proteins,” Journal of Biomedical Materials Research Part A, vol. 92, no. 4, pp. 1528–1537, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. Y. Tamaki, Y. Takakubo, K. Goto et al., “Increased expression of toll-like receptors in aseptic loose periprosthetic tissues and septic synovial membranes around total hip implants,” Journal of Rheumatology, vol. 36, no. 3, pp. 598–608, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. H. Kumar, T. Kawai, and S. Akira, “Toll-like receptors and innate immunity,” Biochemical and Biophysical Research Communications, vol. 388, no. 4, pp. 621–625, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. K. Ohashi, V. Burkart, S. Flohé, and H. Kolb, “Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex,” The Journal of Immunology, vol. 164, no. 2, pp. 558–561, 2000. View at Scopus
  46. L. Hou, H. Sasaki, and P. Stashenko, “Toll-like receptor 4-deficient mice have reduced bone destruction following mixed anaerobic infection,” Infection and Immunity, vol. 68, no. 8, pp. 4681–4687, 2000. View at Publisher · View at Google Scholar · View at Scopus
  47. L. Zhuang, J. Y. Jung, E. W. Wang et al., “Pseudomonas aeruginosa lipopolysaccharide induces osteoclastogenesis through a toll-like receptor 4 mediated pathway in vitro and in vivo,” Laryngoscope, vol. 117, no. 5, pp. 841–847, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. Y. Bi, J. M. Seabold, S. G. Kaar et al., “Adherent endotoxin on orthopedic wear particles stimulates cytokine production and osteoclast differentiation,” Journal of Bone and Mineral Research, vol. 16, no. 11, pp. 2082–2091, 2001. View at Scopus
  49. J. L. Nalepka, M. J. Lee, M. J. Kraay et al., “Lipopolysaccharide found in aseptic loosening of patients with inflammatory arthritis,” Clinical Orthopaedics and Related Research, no. 451, pp. 229–235, 2006. View at Publisher · View at Google Scholar · View at Scopus
  50. R. Maitra, C. C. Clement, B. Scharf et al., “Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis,” Molecular Immunology, vol. 47, no. 2-3, pp. 175–184, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. B. J. Rollins, “Chemokines,” Blood, vol. 90, no. 3, pp. 909–928, 1997. View at Scopus
  52. E. J. Fernandez and E. Lolis, “Structure, function, and inhibition of chemokines,” Annual Review of Pharmacology and Toxicology, vol. 42, pp. 469–499, 2002. View at Publisher · View at Google Scholar · View at Scopus
  53. A. Zlotnik and O. Yoshie, “Chemokines: a new classification system and their role in immunity,” Immunity, vol. 12, no. 2, pp. 121–127, 2000. View at Scopus
  54. J. E. Pease and T. J. Williams, “Chemokines and their receptors in allergic disease,” Journal of Allergy and Clinical Immunology, vol. 118, no. 2, pp. 305–318, 2006. View at Publisher · View at Google Scholar · View at Scopus
  55. S. J. Allen, S. E. Crown, and T. M. Handel, “Chemokine: receptor structure, interactions, and antagonism,” Annual Review of Immunology, vol. 25, pp. 787–820, 2007. View at Publisher · View at Google Scholar · View at Scopus
  56. M. Lind, M. C. D. Trindade, D. J. Schurman, S. B. Goodman, and R. L. Smith, “Monocyte migration inhibitory factor synthesis and gene expression in particle-activated macrophages,” Cytokine, vol. 12, no. 7, pp. 909–913, 2000. View at Publisher · View at Google Scholar · View at Scopus
  57. Y. Nakashima, D. H. Sun, M. C. D. Trindade et al., “Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles,” Journal of Bone and Joint Surgery Series B, vol. 81, no. 1, pp. 155–162, 1999. View at Publisher · View at Google Scholar · View at Scopus
  58. B. Yaszay, M. C. D. Trindade, M. Lind, S. B. Goodman, and R. L. Smith, “Fibroblast expression of C-C chemokines in response to orthopaedic biomaterial particle challenge in vitro,” Journal of Orthopaedic Research, vol. 19, no. 5, pp. 970–976, 2001. View at Publisher · View at Google Scholar · View at Scopus
  59. P. G. Ren, Z. Huang, T. Ma, S. Biswal, R. L. Smith, and S. B. Goodman, “Surveillance of systemic trafficking of macrophages induced by UHMWPE particles in nude mice by noninvasive imaging,” Journal of Biomedical Materials Research Part A, vol. 94, no. 3, pp. 706–711, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. P. G. Ren, A. Irani, Z. Huang, T. Ma, S. Biswal, and S. B. Goodman, “Continuous infusion of UHMWPE particles induces increased bone macrophages and osteolysis,” Clinical Orthopaedics and Related Research, vol. 469, no. 1, pp. 113–122, 2011. View at Publisher · View at Google Scholar · View at Scopus
  61. D. G. Remick, “Interleukin-8,” Critical Care Medicine, vol. 33, no. 12, supplement, pp. S466–S467, 2005. View at Publisher · View at Google Scholar · View at Scopus
  62. J. J. Rose, J. F. Foley, P. M. Murphy, and S. Venkatesan, “On the mechanism and significance of ligand-induced internalization of human neutrophil chemokine receptors CXCR1 and CXCR2,” The Journal of Biological Chemistry, vol. 279, no. 23, pp. 24372–24386, 2004. View at Publisher · View at Google Scholar · View at Scopus
  63. D. J. J. Waugh and C. Wilson, “The interleukin-8 pathway in cancer,” Clinical Cancer Research, vol. 14, no. 21, pp. 6735–6741, 2008. View at Publisher · View at Google Scholar · View at Scopus
  64. A. S. Shanbhag, J. J. Jacobs, J. Black, J. O. Galante, and T. T. Glant, “Cellular mediators secreted by interfacial membranes obtained at revision total hip arthroplasty,” Journal of Arthroplasty, vol. 10, no. 4, pp. 498–506, 1995. View at Publisher · View at Google Scholar · View at Scopus
  65. A. Sabokbar and N. Rushton, “Role of inflammatory mediators and adhesion molecules in the pathogenesis of aseptic loosening in total hip arthroplasties,” Journal of Arthroplasty, vol. 10, no. 6, pp. 810–816, 1995. View at Scopus
  66. E. A. Fritz, T. T. Glant, C. Vermes, J. J. Jacobs, and K. A. Roebuck, “Titanium particles induce the immediate early stress responsive chemokines IL-8 and MCP-1 in osteoblasts,” Journal of Orthopaedic Research, vol. 20, no. 3, pp. 490–498, 2002. View at Publisher · View at Google Scholar · View at Scopus
  67. E. A. Fritz, J. J. Jacobs, T. T. Glant, and K. A. Roebuck, “Chemokine IL-8 induction by particulate wear debris in osteoblasts is mediated by NF-κB,” Journal of Orthopaedic Research, vol. 23, no. 6, pp. 1249–1257, 2005. View at Publisher · View at Google Scholar · View at Scopus
  68. E. A. Fritz, T. T. Glant, C. Vermes, J. J. Jacobs, and K. A. Roebuck, “Chemokine gene activation in human bone marrow-derived osteoblasts following exposure to particulate wear debris,” Journal of Biomedical Materials Research Part A, vol. 77, no. 1, pp. 192–201, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. K. Lochner, A. Fritsche, A. Jonitz et al., “The potential role of human osteoblasts for periprosthetic osteolysis following exposure to wear particles,” International Journal of Molecular Medicine, vol. 28, no. 6, pp. 1055–1063, 2011. View at Publisher · View at Google Scholar · View at Scopus
  70. A. M. Kaufman, C. I. Alabre, H. E. Rubash, and A. S. Shanbhag, “Human macrophage response to UHMWPE, TiAlV, CoCr, and alumina particles: analysis of multiple cytokines using protein arrays,” Journal of Biomedical Materials Research Part A, vol. 84, no. 2, pp. 464–474, 2008. View at Publisher · View at Google Scholar · View at Scopus
  71. A. J. Valente, D. T. Graves, C. E. Vialle-Valentin, R. Delgado, and C. J. Schwartz, “Purification of a monocyte chemotactic factor secreted by nonhuman primate vascular cells in culture,” Biochemistry, vol. 27, no. 11, pp. 4162–4168, 1988. View at Scopus
  72. K. Matsushima, C. G. Larsen, G. C. DuBois, and J. J. Oppenheim, “Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line,” The Journal of Experimental Medicine, vol. 169, no. 4, pp. 1485–1490, 1989. View at Scopus
  73. I. F. Charo and M. B. Taubman, “Chemokines in the pathogenesis of vascular disease,” Circulation Research, vol. 95, no. 9, pp. 858–866, 2004. View at Publisher · View at Google Scholar · View at Scopus
  74. F. Balkwill, “Cancer and the chemokine network,” Nature Reviews Cancer, vol. 4, no. 7, pp. 540–550, 2004. View at Scopus
  75. Y. Lu, G. Xiao, D. L. Galson et al., “PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasion in vitro,” International Journal of Cancer, vol. 121, no. 4, pp. 724–733, 2007. View at Publisher · View at Google Scholar · View at Scopus
  76. X. Li, L. Qin, M. Bergenstock, L. M. Bevelock, D. V. Novack, and N. C. Partridge, “Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts,” The Journal of Biological Chemistry, vol. 282, no. 45, pp. 33098–33106, 2007. View at Publisher · View at Google Scholar · View at Scopus
  77. M. C. D. Trindade, D. J. Schurman, W. J. Maloney, S. B. Goodman, and R. L. Smith, “G-protein activity requirement for polymethylmethacrylate and titanium particle-induced fibroblast interleukin-6 and monocyte chemoattractant protein-1 release in vitro,” Journal of Biomedical Materials Research, vol. 51, no. 3, pp. 360–368, 2000. View at Publisher · View at Google Scholar · View at Scopus
  78. V. Dasa, J. M. Kramer, S. L. Gaffen, K. L. Kirkwood, and W. M. Mihalko, “Is monocyte chemotactic protein 1 elevated in aseptic loosening of TKA?: a pilot study,” Clinical Orthopaedics and Related Research, vol. 470, no. 7, pp. 1879–1884, 2012. View at Publisher · View at Google Scholar · View at Scopus
  79. Z. Huang, T. Ma, P. G. Ren, R. L. Smith, and S. B. Goodman, “Effects of orthopedic polymer particles on chemotaxis of macrophages and mesenchymal stem cells,” Journal of Biomedical Materials Research Part A, vol. 94, no. 4, pp. 1264–1269, 2010. View at Publisher · View at Google Scholar · View at Scopus
  80. C. D. L. Ramos, C. Canetti, J. T. Souto et al., “MIP-1α[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-α and LTB4,” Journal of Leukocyte Biology, vol. 78, no. 1, pp. 167–177, 2005. View at Publisher · View at Google Scholar · View at Scopus
  81. M. Maurer and E. Von Stebut, “Macrophage inflammatory protein-1,” International Journal of Biochemistry and Cell Biology, vol. 36, no. 10, pp. 1882–1886, 2004. View at Publisher · View at Google Scholar · View at Scopus
  82. E. Gibon, T. Ma, P.-G. Ren et al., “Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles,” Journal of Orthopaedic Research, vol. 30, no. 4, pp. 547–553, 2012. View at Publisher · View at Google Scholar · View at Scopus
  83. D. Cadosch, O. P. Gautschi, E. Chan, H. P. Simmen, and L. Filgueira, “Titanium induced production of chemokines CCL17/TARC and CCL22/MDC in human osteoclasts and osteoblasts,” Journal of Biomedical Materials Research Part A, vol. 92, no. 2, pp. 475–483, 2010. View at Publisher · View at Google Scholar · View at Scopus