| TLR | Exogenous ligands (PAMPs) | Endogenous ligands (DAMPs) |
| TLR1 | Triacyl lipopeptide Soluble factors | β-defensin 3 | TLR2 (dimerization with TLR1or 6)
| Lipoglycans (mycobacterium) Lipoteichoic acids (gram-positive bacteria) Peptidoglycan (gram-positive bacteria) Zymosan (yeast)
| HSP 60, HSP70, gp96, β-defensin 3, HMGB1, surfactant proteins, HMGB1-nucleosome complexes, serum amyloid A, eosinophil-derived neurotoxin, antiphospholipid antibodies, cardiac myosin, PAUF, CEP, monosodium urate crystals, Biglycan, versican, hyaluronic acid fragments | TLR3 | dsRNA | mRNA | TLR4 | LPS (gram-negative bacteria) Mannan (Candida) Envelope protein (virus) Hsp70 (exogenous) | HMGB1, surfactant proteins, β-defensin 2, HSP60, HSP70, HSP72, HSP22, Gp96, S100A8, S100A9, neutrophil elastase, antiphospholipid antibodies, lactoferrin, serum amyloid A, oxidized LDL, saturated fatty acids, resistin, PAUF, monosodium urate crystals, Biglycan, fibronectin EDA, fibrinogen, tenascin C, Heparin sulphate fragments, Hyaluronic acid fragments | TLR5 | Flagellin (gram-negative bacteria) | Undetermined | TLR6 | Diacylpolypeptide Lipoteichoic acid (gram-positive bacteria) | Undetermined | TLR7/8 | ss RNA (virus) | Antiphospholipid antibodies, cardiac myosin, ss RNA, | TLR9 | CpG motif (bacteria, virus) | IgG-chromatin complexes, mitochondrial DNA | TLR10 | Diacylated peptide? | Immunostimulatory CpG motifs | TLR11 | Profilin-like molecule | Undetermined |
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