BioMed Research International / 2012 / Article / Tab 1 / Review Article
Bone Morphogenetic Proteins in Craniofacial Surgery: Current Techniques, Clinical Experiences, and the Future of Personalized Stem Cell Therapy Table 1 Selected clinical studies using rhBMPs for human cleft reconstruction.
Authors Year Description Main findings Chin et al. [20 ] 2005 Case series using rhBMP-2 in 50 clefts, 43 patients Successful clinical reconstruction in 49/50 clefts; no radiographic evidence provided; several cases treated with distraction osteogenesis Carstens et al. [21 ] 2005 Case report using rhBMP-2 in one patient Distraction assisted in situ osteogenesis followed by rhBMP-2 collagen sponge implantation; new bone in cleft site used to graft onto and reconstruct deformed hemimandible Herford et al. [22 ] 2007 Retrospective review using rhBMP-2 (
) Significant filling of maxillary cleft by new bone in eight out of ten patients in the rhBMP-2 experimental group at four months on CT Dickinson et al. [23 ]
2008 Randomized controlled trial using rhBMP-2 (
) Cleft repairs of skeletally mature patients found to have greater volume of defect filled by new bone measured by CT in the rhBMP-2 group (93%) when compared to the ABG group (63%), a unique finding
Fallucco and Carstens [24 ] 2009 Retrospective cohort study using rhBMP-2 (
) Vertical and transverse filling of maxillary cleft by new bone seen with spiral CT at six months in sixteen of seventeen cleft repairs Alonso et al. [25 ]
2010 Randomized controlled trial using rhBMP-2 (
) Average bone volume measured by CT 5.8% less in rhBMP-2-treated group than in ABG-treated group
ABG: autologous bone graft; CT: computed tomography; rhBMP: recombinant human bone morphogenetic protein.