Review Article

Strategies for Enhancing Vaccine-Induced CTL Antitumor Immune Responses

Figure 2

The regulation of CTLs in the tumor microenvironment. (a) Tumor-induced immunosuppressive mechanisms in the tumor microenvironment. (b) Activated T cells express more CTLA-4, which competitively engages B7 on the surface of DCs to attenuate T-cell activation. The anti-CTLA-4 antibody ipilimumab rescues the CTLA-4-induced immunosuppression.
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