About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 612316, 18 pages
http://dx.doi.org/10.1155/2012/612316
Review Article

Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

1Department of Ophthalmology, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, LA 70112, USA
2Department of Pharmacology, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, LA 70112, USA
3Department of Microbiology, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, LA 70112, USA
4Neuroscience Center, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, LA 70112, USA
5College of Science and Engineering, Tulane University, New Orleans, LA 70118, USA
6Department of Biology, Xavier University of Louisiana, One Drexel Drive, New Orleans, LA 70125, USA
7School of Pharmacy and Health Professions, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA
8Department of Genetics, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, LA 70112, USA
9Department of Biostatistics, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA 70112, USA

Received 6 January 2012; Revised 4 May 2012; Accepted 22 May 2012

Academic Editor: Andre Van Wijnen

Copyright © 2012 Jody M. Webre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The exact mechanisms of HSV-1 establishment, maintenance, latency, reactivation, and also the courses of recurrent ocular infections remain a mystery. Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatments of recurrent ocular disease. Animal models have been used for over sixty years to investigate our concepts and hypotheses of HSV-1 diseases. In this paper we present descriptions and examples of rabbit and mouse eye models of HSV-1 latency, reactivation, and recurrent diseases. We summarize studies in animal models of spontaneous and induced HSV-1 reactivation and recurrent disease. Numerous stimuli that induce reactivation in mice and rabbits are described, as well as factors that inhibit viral reactivation from latency. The key features, advantages, and disadvantages of the mouse and rabbit models in relation to the study of ocular HSV-1 are discussed. This paper is pertinent but not intended to be all inclusive. We will give examples of key papers that have reported novel discoveries related to the review topics.