Table 1: Selected transgenic mice used for the study of ocular HSV-1.

Mouse nameUse of modelAuthor, year (reference no.)

Rag2 (−/−)Study of ICP0 and ICP34.5Halford et al., 1996 [102]
Stat1 (−/−)IFN response to viral infectionPasieka et al., 2011 [103]
INFαβγR (−/−)IFN response to viral infectionPasieka et al., 2011[103]
IRF-3 (−/−)Viral induction of type I INF cascade Menachery and Leib 2009 [36]
Human ApoE 4 (+/+)ApoE4 role in microglia immune responseVitek et al., 2009 [104]
Stat1 (−/−)Enhanced pathogenesis of Stat1 deficient micePasieka et al., 2008 [105]
Human ApoE3 (+/+)Human ApoE4 role in ocular herpes pathogenesisBhattacharjee et al., 2008 [25]
Human ApoE4 (+/+)Human ApoE4 role in ocular herpes pathogenesisBhattacharjee et al., 2008 [25]
p19 (−/−)IL-23 role in the severity of HSV-1 ocular lesionsKim et al., 2008 [106]
ISG15 (−/−)ISG15 role in host response to viral infectionLenschow et al., 2007 [107]
Stat4 (−/−)Cytokine involvement in HSV-1 stromal keratitis eventsBanerjee et al., 2007 [108]
IL-1ra (−/−)IL-1 role in HSV-1 stromal keratitisBiswas et al., 2004 [109]
scid or rag2 (−/−)ICP0 role in viral replicationHalford et al., 2006 [110]
wt and p53 (−/−)Role of p43 in HSV-1 replicationHaenchen et al., 2010 [111]