Table 3: Detection of infectious HSV-1 from latent mice following stimulation.

Mouse strainGenderHSV-1 strainTissue/fluid/identification procedureFrequency of detection of reactivationType or method of inductionUse of modelAuthors, year (reference no.)

BALB/c (inbred)MaleMcKraeEye swabs16/23 (70%)Transcorneal epinephrine iontophoresisReactivationWilley et al., 1984 [44]
NIH-OLA (inbred)NAMcKraeEye wash2/2 (100%)ImmunosuppressantReactivation antigen studiesShimeld et al., 1990 [42]
NIH-OLA (inbred)NAMcKraeEye wash9/9 (100%)Immunosuppressant UV-BReactivation antigen studiesShimeld et al., 1990 [42]
NIH Swiss WebsterMale17 Syn+Eye swab9/20 (45%)Cx and DxLAT facilitates reactivationCook et al., 1991 [49]
NIH Swiss WebsterMaleXC-20, (LAT+)Eye swab6/19 (31.6%)Cx and DxLAT facilitates reactivationCook et al., 1991[49]
NIH Swiss WebsterMaleX10-13 (LAT−)Eye swab1/20 (5%)Cx and DxLAT facilitates reactivationCook et al., 1991[49]
BALB/cFemaleMcKraeEye swab15/28 (54%)NaB in PBSIn vivo HSV-1 reactivationNeumann et al., 2007 [51]
BALB/cFemale17 Syn+Eye swab21/65 (32%)NaB in PBSIn vivo HSV-1 reactivationNeumann et al., 2007 [51]

Cx: cyclophosphamide, Dx: dexamethasone, LAT: latency-associated transcripts, NA: not available, NaB: sodium butyrate, and PBS: phosphate-balanced saline.