Table 4: Inhibition of induced HSV-1 reactivation in latent mice after stimulation.

Mouse strainGenderHSV-1 strainInhibitorFrequency of detection with inhibitorFrequency of detection without inhibitorType or method of inductionAuthors, year (Reference no.)

BALB/cNAMcKraePropranolol12/37 (32%)20/31 (65%)HyperthermiaGebhardt and Kaufman, 1995 [62]
BALB/cFemaleMcKraeAnti-IL-6 antibodies6/20 (30%)14/20 (70%)HyperthermiaKriesel et al., 1997 [114]
BALB/cFemaleMcKraeAnti-IL-6 antibodies2/20 (20%)6/8 (75%)UVBKriesel et al., 1997 [114]
BALB/cFemaleMcKraeACV20/50 (40%)39/50 (78%)HyperthermiaGebhardt et al., 2004 [61]
BALB/cNAMcKraeASA5/36 (14%)11/36 (31%)HyperthermiaGebhardt et al., 2004 [56]
BALB/cFemaleMcKraeCelecoxib11/47 (23%)28/52 (54%)HyperthermiaGebhardt et al., 2005 [115]
BALB/cFemaleMcKraeBromfenac eye drops10/24 (41.7%)16/22 (72.2%)Cx, Dx & hyperthermiaHigaki et al., 2009 [58]
BALB/cNAW strainAlpha blockers2/34 (6%)10/39 (29%)Epinephrine iontophoresisGordon et al., 1990 [90]

ACV: acycloguanosine, ASA: aspirin, and NA: not available.