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HSV-1 strain | Type or method of induction | Frequency of detection of reactivation | Use of model | Authors, year (reference no.) |
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McKrae | Epinephrine iontophoresis | 21/28 (75%) of eyes | Experimental induction | Kwon et al., 1981 [9] |
McKrae | Epinephrine iontophoresis | 9/10 (90%) | Experimental induction | Kwon et al., 1982 [73] |
McKrae | Epinephrine iontophoresis | 15/20 (75%) | Experimental induction | Hill et al., 1983 [74] |
Rodanus | Intramuscular epinephrine | 4/6 | Experimental induction | Laibson and Kibrick, 1966 [75] |
Rodanus | Intramuscular epinephrine | 12/22 | Experimental induction | Laibson and Kibrick, 1967 [76] |
McKrae | Dextro- versus levoepinephrine iontophoresis | 5/5 (100%) with 0.01% both levo and dextro | Experimental induction | Hill et al., 1985 [72] |
McKrae | Dextro- versus levoepinephrine iontophoresis | with 0.005% epi, 5/10 (50%) with dextro, 10/10 (100%) with levo | Experimental induction | Hill et al., 1985 [72] |
McKrae | Iontophoresis of 6-HD with topical epinephrine | 17/17 (100%) with both, 6/10 (60%) with epinephrine; 6/12 (50%) with 6-HD | Experimental induction | Shimomura et al., 1983 [71] |
McKrae | Timolol 0.01% iontophoresis | 18/18 (100%) | Experimental induction | Hill et al., 1987 [81] |
McKrae | 6-HD iontophoresis followed by topical 5% timolol | 12/12 (100%) | Experimental induction | Hill et al., 1987 [81] |
McKrae | Mechanical stimulation of TG | 10/12 (83%) | Experimental induction | Nesburn et al., 1977 [77] 1976 [78] |
McKrae | Electrical induction of TG | 19/23 (83%) of stimuli | Experimental induction | Green et al., 1981 [79] |
McKrae | RK reactivation | 15/140 (11%) | Reproduce induction in animal model | Haruta et al., 1987 [10] |
McKrae | PKP | 2/10 (20%) | PKP induction of reactivation | Beyer et al., 1989 [83] |
McKrae | PKP and immunosuppression | 9/11 (82%) | PKP induction of reactivation | Beyer et al., 1989 [83] |
17Syn+ | BN52021 | 9/10 (90%) | Cryogenic induction with lipoxygenase pathway inhibitor | Beyer et al., 1989 [83] |
McKrae | Cx and Dx | 21/24 (88%) | Induction | Haruta et al., 1989 [88] |
McKrae | Cryogenic injury | 5/7 (71%) | Induction by corneal nerve disruption | Beyer et al., 1990 [84] |
McKrae | Anterior superficial keratectomy | 8/12 (67%) | Induction by corneal nerve disruption | Beyer et al., 1990 [84] |
McKrae | Transsection at corneoscleral limbus | 8/12 (67%) | Induction by corneal nerve disruption | Beyer et al., 1990 [84] |
W Strain | Xalatan | 18/24 (75%) | Induction | Gordon et al., 2003 [15] |
McKrae | Nicotine transdermal |
20/20 (100%) | Induction | Myles et al., 2003 [86] |
McKrae | Antinerve growth factor antibody | 15/16 (93%) | Experimental induction | Hill et al., 1997 [87] |
McKrae | Bupropion | 20/20 (100%) | Inhibition of nicotine reactivation | Myles et al., 2004 [89] |
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