Table 6: induction of HSV-1 reactivation in latently infected rabbits.

HSV-1 strainType or method of inductionFrequency of detection of reactivationUse of modelAuthors, year (reference no.)

McKraeEpinephrine iontophoresis21/28 (75%) of eyesExperimental inductionKwon et al., 1981 [9]
McKraeEpinephrine iontophoresis9/10 (90%)Experimental inductionKwon et al., 1982 [73]
McKraeEpinephrine iontophoresis15/20 (75%)Experimental inductionHill et al., 1983 [74]
RodanusIntramuscular epinephrine4/6Experimental inductionLaibson and Kibrick, 1966 [75]
RodanusIntramuscular epinephrine12/22Experimental inductionLaibson and Kibrick, 1967 [76]
McKraeDextro- versus levoepinephrine iontophoresis5/5 (100%) with 0.01% both levo and dextroExperimental inductionHill et al., 1985 [72]
McKraeDextro- versus levoepinephrine iontophoresiswith 0.005% epi, 5/10 (50%) with dextro, 10/10 (100%) with levoExperimental inductionHill et al., 1985 [72]
McKraeIontophoresis of 6-HD with topical epinephrine17/17 (100%) with both, 6/10 (60%) with epinephrine; 6/12 (50%) with 6-HDExperimental inductionShimomura et al., 1983 [71]
McKraeTimolol 0.01% iontophoresis18/18 (100%)Experimental inductionHill et al., 1987 [81]
McKrae6-HD iontophoresis followed by topical 5% timolol12/12 (100%)Experimental inductionHill et al., 1987 [81]
McKraeMechanical stimulation of TG10/12 (83%)Experimental inductionNesburn et al., 1977 [77]
1976 [78]
McKraeElectrical induction of TG19/23 (83%) of stimuliExperimental inductionGreen et al., 1981 [79]
McKraeRK reactivation15/140 (11%)Reproduce induction in animal modelHaruta et al., 1987 [10]
McKraePKP2/10 (20%)PKP induction of reactivationBeyer et al., 1989 [83]
McKraePKP and immunosuppression9/11 (82%)PKP induction of reactivationBeyer et al., 1989 [83]
17Syn+BN520219/10 (90%)Cryogenic induction with lipoxygenase pathway inhibitorBeyer et al., 1989 [83]
McKraeCx and Dx21/24 (88%)InductionHaruta et al., 1989 [88]
McKraeCryogenic injury5/7 (71%)Induction by corneal nerve disruptionBeyer et al., 1990 [84]
McKraeAnterior superficial keratectomy8/12 (67%)Induction by corneal nerve disruptionBeyer et al., 1990 [84]
McKraeTranssection at corneoscleral limbus8/12 (67%)Induction by corneal nerve disruptionBeyer et al., 1990 [84]
W StrainXalatan18/24 (75%)InductionGordon et al., 2003 [15]
McKraeNicotine transdermal 20/20 (100%)InductionMyles et al., 2003 [86]
McKraeAntinerve growth factor antibody15/16 (93%)Experimental inductionHill et al., 1997 [87]
McKraeBupropion20/20 (100%)Inhibition of nicotine reactivationMyles et al., 2004 [89]

Cx: cyclophosphamide, Dx: dexamethasone, PKP: penetrating keratoplasty, and RK: radial keratotomy.