Table 7: Inhibitor of HSV-1 reactivation in latently infected rabbits.

HSV-1 StrainInhibitorFrequency of detection of reactivation with inhibitorFrequency of detection of reactivation without inhibitorAuthors, year (reference no.)

McKraePropranolol with epinephrine iontophoresis56/84 (67%) with 20 mg/kg;
23/42 (55%) with 200 mg/kb
46/84 (55%) and 20/42 (48%)Garza and Hill, 1997 [82]
McKraePropranolol with Cx and Dx27/56 (48%)29/63 (46%)Garza and Hill, 1997 [82]
17 Syn+Propranolol with epinephrine iontophoresis43/70 (61%) with 5 mg/kg;29/56 (52%) with 200 mg/kg34/70 (49%) and 7/8 (88%)Garza and Hill, 1997 [82]
17 Syn+Propranolol with Cx and Dx24/63 (38%)21/56 (38%)Garza and Hill, 1997 [82]
McKraePropranolol20/264 (7.6%)28/216 (13%)Kaufman et al., 1996 [80]
17 Syn+Propranolol11/336 (3.3%)31/264 (11.7%)Kaufman et al., 1996 [80]
McKraeBupropion9/20 (45%)13/29 (65%)Myles et al., 2004 [89]
McKraeBupropion with nicotine transdermal13/36 (36.1%)35/36 (97.2%)Myles et al., 2004 [89]
W strainAlpha blockers10/14 (71%)13/14 (93%)Gordon et al., 1990 [90]

Cx: cyclophosphamide and Dx: dexamethasone.