Table 8: Induced recurrent corneal lesions in HSV-1 latently infected rabbits.

HSV-1 strainFrequency of detection of reactivationType or method of inductionAuthors/year (reference no.)

McKrae9/10 (90%) SPK; 1/10 (10%) dendrites; 9 epithelial ulcersPKPBeyer et al., 1989 [83]
McKrae11/11 (100%) SPK; 1/11 (9%) dendrites; 9/11 (82%) epithelial ulcersPKP plus Dx (immunosuppressant)Beyer et al., 1989 [83]
17Syn+5/10 (50%); 2/10 (20%) of controlsBN 52021Beyer et al., 1989 [85]
McKrae36/157 (23%)0.1% 6-HD iontophoresis followed by topical 0.1% PropineHill et al., 1987 [116]
McKrae20/24 (83%)Cx and DxHaruta et al., 1989 [88]
McKrae17/34 (50%)0.01% timolol iontophoresisHaruta et al., 1987 [10]
McKrae7/12 (58%)transsection at corneoscleral limbus (corneal nerve disruption)Beyer et al., 1990 [84]

Rabbits were inoculated in the eye. Lesions were identified using slit-lamp examination. Cx: cyclophosphamide, Dx: dexamethasone, PKP: penetrating keratoplasty, and SPK: superficial punctate keratitis.