Table 9: Reagents or methods that can inhibit or induce HSV-1 reactivation for rabbits and mice.

Reagents or methodsMice latently infected with HSV-1Rabbits latently infected with HSV-1Reference(s)

Epinephrine iontophoresisInduces [44]Induces [9, 7274, 90]Willey et al., 1984 [44]
Gordon et al., 1990 [90]
Kwon et al., 1981 [9]
Kwon et al., 1982 [73]
Hill et al., 1983 [74]
Hill et al., 1985 [72]
UV-BInduces [42, 114]Shimeld et al., 1990 [42]
Kriesel et al., 1997 [114]
Cx and DxInduces [49, 58]Induces [88]Cook et al., 1991 [49],
Higaki et al., 2009 [58],
Haruta et al., 1989 [10]
Haruta et al., 1989 [88]
NaB in PBSInduces [51]Neumann et al., 2007 [51]
HyperthermiaInduces [56, 58, 61, 62, 114, 115]Gebhardt and Kaufman, 1995 [62]
Kriesel et al., 1997 [114]
Gebhardt et al., 2004 [61]
Gebhardt et al., 2004 [56]
Gebhardt et al., 2005 [115]
Higaki et al., 2009 [58]
PropranololInhibits [62]Inhibits [80]Gebhardt and Kaufman, 1995 [62]
Kaufman et al., 1996 [80]
Anti-IL-6 antibodiesInhibits [114]Kriesel et al., 1997 [114]
ASAInhibits [115]Gebhardt et al., 2004 [56]
CelecoxibInhibits [115]Gebhardt et al., 2005 [115]
BromfenacInhibits [58]Higaki et al., 2009 [58]
Alpha blockersInhibits [90]Gordon et al., 1990 [90]
6-HD iontophoresisInduces [81]Hill et al., 1987 [81]
TimololInduces [81, 117]Hill et al., 1987 [81]
Haruta et al., 1988 [117]
Mechanical stimulation of TGInduces [77]Nesburn et al., 1977 [77]
Electrical stimulation of TGInduces [79]Green et al., 1981 [79]
PKPInduces [83]Beyer et al., 1989 [83]
Platelet activating factor antagonistInduces [85]Beyer et al., 1989 [85]
Cryogenic injuryInduces [84]Beyer et al., 1990 [84]
Anterior superficial keratectomyInduces [84]Beyer et al., 1990 [84]
Transsection at corneoscleral limbusInduces [84]Beyer et al., 1990 [84]
XalatanInduces [15]Gordon et al., 2003 [15]
Nicotine transdermalInduces [86]Myles et al., 2003 [86]
Antinerve growth factor antibodyInduces [87]Hill et al., 1997 [87]
BupropionInhibits [89]Myles et al., 2004 [89]