Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

Table 9

Reagents or methods that can inhibit or induce HSV-1 reactivation for rabbits and mice.

Reagents or methods	Mice latently infected with HSV-1	Rabbits latently infected with HSV-1	Reference(s)
Epinephrine iontophoresis	Induces [44]	Induces [9, 72–74, 90]	Willey et al., 1984 [44]; Gordon et al., 1990 [90]; Kwon et al., 1981 [9]; Kwon et al., 1982 [73]; Hill et al., 1983 [74]; Hill et al., 1985 [72]
UV-B	Induces [42, 114]		Shimeld et al., 1990 [42]; Kriesel et al., 1997 [114]
Cx and Dx	Induces [49, 58]	Induces [88]	Cook et al., 1991 [49],; Higaki et al., 2009 [58],; Haruta et al., 1989 [10]; Haruta et al., 1989 [88]
NaB in PBS	Induces [51]		Neumann et al., 2007 [51]
Hyperthermia	Induces [56, 58, 61, 62, 114, 115]		Gebhardt and Kaufman, 1995 [62]; Kriesel et al., 1997 [114]; Gebhardt et al., 2004 [61]; Gebhardt et al., 2004 [56]; Gebhardt et al., 2005 [115]; Higaki et al., 2009 [58]
Propranolol	Inhibits [62]	Inhibits [80]	Gebhardt and Kaufman, 1995 [62]; Kaufman et al., 1996 [80]
Anti-IL-6 antibodies	Inhibits [114]		Kriesel et al., 1997 [114]
ASA	Inhibits [115]		Gebhardt et al., 2004 [56]
Celecoxib	Inhibits [115]		Gebhardt et al., 2005 [115]
Bromfenac	Inhibits [58]		Higaki et al., 2009 [58]
Alpha blockers	Inhibits [90]		Gordon et al., 1990 [90]
6-HD iontophoresis		Induces [81]	Hill et al., 1987 [81]
Timolol		Induces [81, 117]	Hill et al., 1987 [81]; Haruta et al., 1988 [117]
Mechanical stimulation of TG		Induces [77]	Nesburn et al., 1977 [77]
Electrical stimulation of TG		Induces [79]	Green et al., 1981 [79]
PKP		Induces [83]	Beyer et al., 1989 [83]
Platelet activating factor antagonist		Induces [85]	Beyer et al., 1989 [85]
Cryogenic injury		Induces [84]	Beyer et al., 1990 [84]
Anterior superficial keratectomy		Induces [84]	Beyer et al., 1990 [84]
Transsection at corneoscleral limbus		Induces [84]	Beyer et al., 1990 [84]
Xalatan		Induces [15]	Gordon et al., 2003 [15]
Nicotine transdermal		Induces [86]	Myles et al., 2003 [86]
Antinerve growth factor antibody		Induces [87]	Hill et al., 1997 [87]
Bupropion		Inhibits [89]	Myles et al., 2004 [89]