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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 623019, 11 pages
http://dx.doi.org/10.1155/2012/623019
Review Article

Role of Nitrative and Oxidative DNA Damage in Inflammation-Related Carcinogenesis

1Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, 514-8507, Japan
2Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, 513-8670, Japan
3Faculty of Health Science, Suzuka University of Medical Science, Suzuka, 510-0293, Japan

Received 28 July 2011; Accepted 7 October 2011

Academic Editor: Vassilis Gorgoulis

Copyright © 2012 Mariko Murata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. M. Coussens and Z. Werb, “Inflammation and cancer,” Nature, vol. 420, no. 6917, pp. 860–867, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. IARC, “Chronic infections,” in World Cancer Report, B. W. Stewart and P. Kleihues, Eds., pp. 56–61, IARC Press, Lyon, France, 2003.
  3. S. Kawanishi and Y. Hiraku, “Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation,” Antioxidants and Redox Signaling, vol. 8, no. 5-6, pp. 1047–1058, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. S. Kawanishi, Y. Hiraku, and S. Oikawa, “Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging,” Mutation Research, vol. 488, no. 1, pp. 65–76, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Ohshima, M. Tatemichi, and T. Sawa, “Chemical basis of inflammation-induced carcinogenesis,” Archives of Biochemistry and Biophysics, vol. 417, no. 1, pp. 3–11, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. S. D. Bruner, D. P. G. Norman, and G. L. Verdine, “Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA,” Nature, vol. 403, no. 6772, pp. 859–866, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. F. Farinati, R. Cardin, P. Degan et al., “Oxidative DNA damage in circulating leukocytes occurs as an early event in chronic HCV infection,” Free Radical Biology and Medicine, vol. 27, no. 11-12, pp. 1284–1291, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Akaike, S. Fujii, A. Kato et al., “Viral mutation accelerated by nitric oxide production during infection in vivo,” The FASEB Journal, vol. 14, no. 10, pp. 1447–1454, 2000. View at Scopus
  9. B. Halliwell, “Oxygen and nitrogen are pro-carcinogens. Damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition,” Mutation Research, vol. 443, no. 1-2, pp. 37–52, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. V. Yermilov, J. Rubio, M. Becchi, M. D. Friesen, B. Pignatelli, and H. Ohshima, “Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro,” Carcinogenesis, vol. 16, no. 9, pp. 2045–2050, 1995. View at Scopus
  11. V. Yermilov, J. Rubio, and H. Ohshima, “Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination,” FEBS Letters, vol. 376, no. 3, pp. 207–210, 1995. View at Publisher · View at Google Scholar · View at Scopus
  12. L. A. Loeb and B. D. Preston, “Mutagenesis by apurinic/apyrimidinic sites,” Annual Review of Genetics, vol. 20, pp. 201–230, 1986.
  13. L. Haracska, I. Unk, R. E. Johnson et al., “Roles of yeast DNA polymerases δ and ζ of Rev 1 in the bypass of abasic sites,” Genes and Development, vol. 15, no. 8, pp. 945–954, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. X. Wu, K. Takenaka, E. Sonoda et al., “Critical roles for polymerase ζ in cellular tolerance to nitric oxide-induced DNA damage,” Cancer Research, vol. 66, no. 2, pp. 748–754, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. N. Suzuki, M. Yasui, N. E. Geacintov, V. Shafirovich, and S. Shibutani, “Miscoding events during DNA synthesis past the nitration-damaged base 8-nitroguanine,” Biochemistry, vol. 44, no. 25, pp. 9238–9245, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. S. Akatsuka and S. Toyokuni, “Genome-scale approaches to investigate oxidative DNA damage,” Journal of Clinical Biochemistry and Nutrition, vol. 47, no. 2, pp. 91–97, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. S. Pinlaor, Y. Hiraku, N. Ma et al., “Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: a model of inflammation-mediated carcinogenesis,” Nitric Oxide, vol. 11, no. 2, pp. 175–183, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. T. Patel, “Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States,” Hepatology, vol. 33, no. 6, pp. 1353–1357, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. S. Sriamporn, P. Pisani, V. Pipitgool, K. Suwanrungruang, S. Kamsa-ard, and D. H. Parkin, “Prevalence of Opisthorchis viverrini infection and incidence of cholangiocarcinoma in Khon Kaen, Northeast Thailand,” Tropical Medicine and International Health, vol. 9, no. 5, pp. 588–594, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. B. Sripa and S. Kaewkes, “Localisation of parasite antigens and inflammatory responses in experimental opisthorchiasis,” International Journal for Parasitology, vol. 30, no. 6, pp. 735–740, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Riganti, S. Pungpak, B. Punpoowong, D. Bunnag, and T. Harinasuta, “Human pathology of Opisthorchis viverrini infection: a comparison of adults and children,” The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 20, no. 1, pp. 95–100, 1989. View at Scopus
  22. S. Pinlaor, Y. Hiraku, P. Yongvanit et al., “iNOS-dependent DNA damage via NF-κB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel,” International Journal of Cancer, vol. 119, no. 5, pp. 1067–1072, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. S. Pinlaor, N. Ma, Y. Hiraku et al., “Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7, 8-dihydro-2-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase,” Carcinogenesis, vol. 25, no. 8, pp. 1535–1542, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. S. Pinlaor, P. Yongvanit, Y. Hiraku et al., “8-nitroguanine formation in the liver of hamsters infected with Opisthorchis viverrini,” Biochemical and Biophysical Research Communications, vol. 309, no. 3, pp. 567–571, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Pinlaor, S. Tada-Oikawa, Y. Hiraku et al., “Opisthorchis viverrini antigen induces the expression of Toll-like receptor 2 in macrophage RAW cell line,” International Journal for Parasitology, vol. 35, no. 6, pp. 591–596, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. S. Pinlaor, B. Sripa, N. Ma et al., “Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion,” World Journal of Gastroenterology, vol. 11, no. 30, pp. 4644–4649, 2005. View at Scopus
  27. R. Thanan, M. Murata, S. Pinlaor et al., “Urinary 8-oxo-7, 8-dihydro-2-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 3, pp. 518–524, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. R. M. Peek Jr. and M. J. Blaser, “Helicobacter pylori and gastrointestinal tract adenocarcinomas,” Nature Reviews Cancer, vol. 2, no. 1, pp. 28–37, 2002. View at Scopus
  29. O. Handa, Y. Naito, and T. Yoshikawa, “Helicobacter pylori: a ROS-inducing bacterial species in the stomach,” Inflammation Research, vol. 59, no. 12, pp. 997–1003, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. S. Maeda, M. Akanuma, Y. Mitsuno et al., “Distinct mechanism of Helicobacter pylori-mediated NF-κB activation between gastric cancer cells and monocytic cells,” Journal of Biological Chemistry, vol. 276, no. 48, pp. 44856–44864, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. E. Pikarsky, R. M. Porat, I. Stein et al., “NF-κB functions as a tumour promoter in inflammation-associated cancer,” Nature, vol. 431, no. 7007, pp. 461–466, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. Y. J. Surh, K. S. Chun, H. H. Cha et al., “Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation,” Mutation Research, vol. 480-481, pp. 243–268, 2001. View at Scopus
  33. E. E. Mannick, L. E. Bravo, G. Zarama et al., “Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants,” Cancer Research, vol. 56, no. 14, pp. 3238–3243, 1996. View at Scopus
  34. S. Fu, K. S. Ramanujam, A. Wong et al., “Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis,” Gastroenterology, vol. 116, no. 6, pp. 1319–1329, 1999. View at Publisher · View at Google Scholar · View at Scopus
  35. S. O. Cho, J. W. Lim, K. H. Kim, and H. Kim, “Involvement of ras and AP-1 in Helicobacter pylori-induced expression of COX-2 and iNOS in gastric epithelial AGS cells,” Digestive Diseases and Sciences, vol. 55, no. 4, pp. 988–996, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  36. N. Ma, Y. Adachi, Y. Hiraku et al., “Accumulation of 8-nitroguanine in human gastric epithelium induced by Helicobacter pylori infection,” Biochemical and Biophysical Research Communications, vol. 319, no. 2, pp. 506–510, 2004. View at Publisher · View at Google Scholar · View at PubMed
  37. IARC, “cancer of female reproductive tract,” in World Cancer Report, B. W. Stewart and P. Kleihues, Eds., pp. 215–222, IARC Press, Lyon, France, 2003.
  38. Y. Hiraku, T. Tabata, N. Ma, M. Murata, X. Ding, and S. Kawanishi, “Nitrative and oxidative DNA damage in cervical intraepithelial neoplasia associated with human papilloma virus infection,” Cancer Science, vol. 98, no. 7, pp. 964–972, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. R. Klaes, T. Friedrich, D. Spitkovsky et al., “Overexpression of p16ink4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri,” International Journal of Cancer, vol. 92, no. 2, pp. 276–284, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. T. Sano, T. Oyama, K. Kashiwabara, T. Fukuda, and T. Nakajima, “Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions,” American Journal of Pathology, vol. 153, no. 6, pp. 1741–1748, 1998. View at Scopus
  41. M. von Knebel Doeberitz, “New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections,” European Journal of Cancer, vol. 38, no. 17, pp. 2229–2242, 2002. View at Publisher · View at Google Scholar · View at Scopus
  42. J. L. Wang, B. Y. Zheng, X. D. Li, T. Angstrom, M. S. Lindstrom, and K. L. Wallin, “Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer,” Clinical Cancer Research, vol. 10, no. 7, pp. 2407–2414, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. A. L. McDermott, S. N. Dutt, and J. C. Watkinson, “The aetiology of nasopharyngeal carcinoma,” Clinical Otolaryngology and Allied Sciences, vol. 26, no. 2, pp. 82–92, 2001. View at Publisher · View at Google Scholar · View at Scopus
  44. H. W. Lo, S. C. Hsu, M. Ali-Seyed et al., “Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway,” Cancer Cell, vol. 7, no. 6, pp. 575–589, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  45. E. Tedeschi, M. Menegazzi, D. Margotto, H. Suzuki, U. Forstermann, and H. Kleinert, “Anti-inflammatory actions of St. John's wort: inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1α (STAT-1α) activation,” Journal of Pharmacology and Experimental Therapeutics, vol. 307, no. 1, pp. 254–261, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  46. H. Chen, L. Hutt-Fletcher, L. Cao, and S. D. Hayward, “A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus,” Journal of Virology, vol. 77, no. 7, pp. 4139–4148, 2003. View at Publisher · View at Google Scholar · View at Scopus
  47. Y. Tao, X. Song, X. Deng et al., “Nuclear accumulation of epidermal growth factor receptor and acceleration of G1/S stage by Epstein-Barr-encoded oncoprotein latent membrane protein 1,” Experimental Cell Research, vol. 303, no. 2, pp. 240–251, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  48. J. S. Yu, H. C. Tsai, C. C. Wu et al., “Induction of inducible nitric oxide synthase by Epstein-Barr virus B95-8-derived LMP1 in Balb/3T3 cells promotes stress-induced cell death and impairs LMP1-mediated transformation,” Oncogene, vol. 21, no. 52, pp. 8047–8061, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  49. Y. J. Huang, B. B. Zhang, N. Ma, M. Murata, A. Z. Tang, and G. W. Huang, “Nitrative and oxidative DNA damage as potential survival biomarkers for nasopharyngeal carcinoma,” Medical Oncology, vol. 28, no. 1, pp. 377–384, 2011. View at Publisher · View at Google Scholar · View at PubMed
  50. N. Ma, M. Kawanishi, Y. Hiraku et al., “Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma: the relation to STAT3 activation and EGFR expression,” International Journal of Cancer, vol. 122, no. 11, pp. 2517–2525, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  51. T. Poynard, M. F. Yuen, V. Ratziu, and C. L. Lai, “Viral hepatitis C,” The Lancet, vol. 362, no. 9401, pp. 2095–2100, 2003. View at Publisher · View at Google Scholar · View at Scopus
  52. B. Bressac, M. Kew, J. Wands, and M. Ozturk, “Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa,” Nature, vol. 350, no. 6317, pp. 429–431, 1991. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  53. W. H. Caselmann and M. Alt, “Hepatitis C virus infection as a major risk factor for hepatocellular carcinoma,” Journal of Hepatology, vol. 24, no. 2, supplement, pp. 61–66, 1996. View at Scopus
  54. I. C. Hsu, R. A. Metcalf, T. Sun, J. A. Welsh, N. J. Wang, and C. C. Harris, “Mutational hotspot in the p53 gene in human hepatocellular carcinomas,” Nature, vol. 350, no. 6317, pp. 427–428, 1991. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  55. T. Oda, H. Tsuda, A. Scarpa, M. Sakamoto, and S. Hirohashi, “p53 gene mutation spectrum in hepatocellular carcinoma,” Cancer Research, vol. 52, no. 22, pp. 6358–6364, 1992. View at Scopus
  56. S. Horiike, S. Kawanishi, M. Kaito et al., “Accumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C,” Journal of Hepatology, vol. 43, no. 3, pp. 403–410, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  57. N. Fujita, S. Horiike, R. Sugimoto et al., “Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients,” Free Radical Biology and Medicine, vol. 42, no. 3, pp. 353–362, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  58. H. Tanaka, N. Fujita, R. Sugimoto et al., “Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C,” British Journal of Cancer, vol. 98, no. 3, pp. 580–586, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  59. N. Fujita, R. Sugimoto, N. Ma et al., “Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C,” Journal of Viral Hepatitis, vol. 15, no. 7, pp. 498–507, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  60. N. Ma, R. Thanan, H. Kobayashi, et al., “Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosoma haematobium infection,” Biochemical and Biophysical Research Communications, vol. 414, no. 2, pp. 344–349, 2011. View at Publisher · View at Google Scholar · View at PubMed
  61. Y. Hiraku, S. Kawanishi, T. Ichinose, and M. Murata, “The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis,” Annals of the New York Academy of Sciences, vol. 1203, pp. 15–22, 2010. View at Publisher · View at Google Scholar · View at PubMed
  62. P. Chaiyarit, N. Ma, Y. Hiraku et al., “Nitrative and oxidative DNA damage in oral lichen planus in relation to human oral carcinogenesis,” Cancer Science, vol. 96, no. 9, pp. 553–559, 2005. View at Publisher · View at Google Scholar · View at PubMed
  63. X. Ding, Y. Hiraku, N. Ma et al., “Inducible nitric oxide synthase-dependent DNA damage in mouse model of inflammatory bowel disease,” Cancer Science, vol. 96, no. 3, pp. 157–163, 2005. View at Publisher · View at Google Scholar · View at PubMed
  64. Y. Hoki, Y. Hiraku, N. Ma et al., “iNOS-dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis,” Cancer Science, vol. 98, no. 2, pp. 163–168, 2007. View at Publisher · View at Google Scholar · View at PubMed
  65. Y. Hoki, M. Murata, Y. Hiraku et al., “8-nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer,” Oncology Reports, vol. 18, no. 5, pp. 1165–1169, 2007.
  66. R. P. Schins, “Mechanisms of genotoxicity of particles and fibers,” Inhalation Toxicology, vol. 14, no. 1, pp. 57–78, 2002. View at Publisher · View at Google Scholar · View at PubMed
  67. IARC, “Asbestos,” IRAC Mongraphs on the Evalution of Carcinogenic Risk to Humans, vol. 7, supplement 1, pp. 106–116, 1987.
  68. J. E. Craighead, J. L. Abraham, A. Churg et al., “The pathology of asbestos-associated diseases of the lungs and pleural cavities: diagnostic criteria and proposed grading schema. Report of the pneumoconiosis committee of the college of American pathologists and the national institute for occupational safety and health,” Archives of Pathology and Laboratory Medicine, vol. 106, no. 11, pp. 544–596, 1982.
  69. C. B. Manning, V. Vallyathan, and B. T. Mossman, “Diseases caused by asbestos: mechanisms of injury and disease development,” International Immunopharmacology, vol. 2, no. 2-3, pp. 191–200, 2002. View at Publisher · View at Google Scholar
  70. J. P. Eiserich, M. Hristova, C. E. Cross et al., “Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils,” Nature, vol. 391, no. 6665, pp. 393–397, 1998. View at Publisher · View at Google Scholar · View at PubMed
  71. J. P. Gaut, J. Byun, H. D. Tran et al., “Myeloperoxidase produces nitrating oxidants in vivo,” Journal of Clinical Investigation, vol. 109, no. 10, pp. 1311–1319, 2002. View at Publisher · View at Google Scholar
  72. S. Tanaka, N. Choe, D. R. Hemenway, S. Zhu, S. Matalon, and E. Kagan, “Asbestos inhalation induces reactive nitrogen species and nitrotyrosine formation in the lungs and pleura of the rat,” Journal of Clinical Investigation, vol. 102, no. 2, pp. 445–454, 1998.
  73. A. van der Vliet, J. P. Eiserich, M. K. Shigenaga, and C. E. Cross, “Reactive nitrogen species and tyrosine nitration in the respiratory tract: epiphenomena or a pathobiologic mechanism of disease?” American Journal of Respiratory and Critical Care Medicine, vol. 160, no. 1, pp. 1–9, 1999.
  74. A. Haegens, A. van der Vliet, K. J. Butnor et al., “Asbestos-induced lung inflammation and epithelial cell proliferation are altered in myeloperoxidase-null mice,” Cancer Research, vol. 65, no. 21, pp. 9670–9677, 2005. View at Publisher · View at Google Scholar · View at PubMed
  75. A. Ekbom, C. Helmick, M. Zack, and H. O. Adami, “Increased risk of large-bowel cancer in Crohn's disease with colonic involvement,” The Lancet, vol. 336, no. 8711, pp. 357–359, 1990.
  76. L. J. Hofseth, S. Saito, S. P. Hussain et al., “Nitric oxide-induced cellular stress and p53 activation in chronic inflammation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 1, pp. 143–148, 2003. View at Publisher · View at Google Scholar · View at PubMed
  77. I. I. Singer, D. W. Kawka, S. Scott et al., “Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease,” Gastroenterology, vol. 111, no. 4, pp. 871–885, 1996.
  78. H. Wiseman and B. Halliwell, “Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer,” Biochemical Journal, vol. 313, part 1, pp. 17–29, 1996.
  79. C. Scully, M. Beyli, M. C. Ferreiro et al., “Update on oral lichen planus: etiopathogenesis and management,” Critical Reviews in Oral Biology and Medicine, vol. 9, no. 1, pp. 86–122, 1998.
  80. M. D. Mignogna, S. Fedele, L. Lo Russo, L. Lo Muzio, and E. Bucci, “Immune activation and chronic inflammation as the cause of malignancy in oral lichen planus: is there any evidence?” Oral Oncology, vol. 40, no. 2, pp. 120–130, 2004. View at Publisher · View at Google Scholar
  81. B. W. Neville and T. A. Day, “Oral cancer and precancerous lesions,” CA: A Cancer Journal for Clinicians, vol. 52, no. 4, pp. 195–215, 2002.
  82. J. Reibel, “Prognosis of oral pre-malignant lesions: significance of clinical, histopathological, and molecular biological characteristics,” Critical Reviews in Oral Biology & Medicine, vol. 14, no. 1, pp. 47–62, 2003.
  83. N. Ma, T. Tagawa, Y. Hiraku, M. Murata, X. Ding, and S. Kawanishi, “8-nitroguanine formation in oral leukoplakia, a premalignant lesion,” Nitric Oxide, vol. 14, no. 2, pp. 137–143, 2006. View at Publisher · View at Google Scholar · View at PubMed
  84. J. J. Lee, M. Y. Kuo, S. J. Cheng et al., “Higher expressions of p53 and proliferating cell nuclear antigen (PCNA) in atrophic oral lichen planus and patients with areca quid chewing,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, vol. 99, no. 4, pp. 471–478, 2005. View at Publisher · View at Google Scholar · View at PubMed
  85. A. Jemal, R. C. Tiwari, T. Murray et al., “Cancer Statistics, 2004,” CA: A Cancer Journal for Clinicians, vol. 54, no. 1, pp. 8–29, 2004.
  86. S. W. Weiss and F. M. Enzinger, “Malignant fibrous histiocytoma. An analysis of 200 cases,” Cancer, vol. 41, no. 6, pp. 2250–2266, 1978.
  87. A. Belal, A. Kandil, A. Allam et al., “Malignant fibrous histiocytoma: a retrospective study of 109 cases,” American Journal of Clinical Oncology, vol. 25, no. 1, pp. 16–22, 2002. View at Publisher · View at Google Scholar
  88. R. L. Randall, K. H. Albritton, B. J. Ferney, and L. Layfield, “Malignant fibrous histiocytoma of soft tissue: an abandoned diagnosis,” The American Journal of Orthopedics, vol. 33, no. 12, pp. 602–608, 2004.
  89. M. F. Melhem, A. I. Meisler, R. Saito, G. G. Finley, H. R. Hockman, and R. A. Koski, “Cytokines in inflammatory malignant fibrous histiocytoma presenting with leukemoid reaction,” Blood, vol. 82, no. 7, pp. 2038–2044, 1993.
  90. K. K. Richter, D. M. Parham, J. Scheele, R. Hinze, and F. W. Rath, “Presarcomatous lesions of experimentally induced sarcomas in rats: morphologic, histochemical, and immunohistochemical features,” In Vivo, vol. 13, no. 4, pp. 349–355, 1999.
  91. F. Michor, Y. Iwasa, B. Vogelstein, C. Lengauer, and M. A. Nowak, “Can chromosomal instability initiate tumorigenesis?” Seminars in Cancer Biology, vol. 15, no. 1, pp. 43–49, 2005. View at Publisher · View at Google Scholar · View at PubMed
  92. N. P. Degtyareva, L. Chen, P. Mieczkowski, T. D. Petes, and P. W. Doetsch, “Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae,” Molecular and Cellular Biology, vol. 28, no. 17, pp. 5432–5445, 2008. View at Publisher · View at Google Scholar · View at PubMed
  93. B. Trouiller, R. Reliene, A. Westbrook, P. Solaimani, and R. H. Schiestl, “Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice,” Cancer Research, vol. 69, no. 22, pp. 8784–8789, 2009. View at Publisher · View at Google Scholar · View at PubMed
  94. K. Mazan-Mamczarz, P. R. Hagner, Y. Zhang et al., “ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes,” Blood, vol. 117, no. 8, pp. 2441–2450, 2011. View at Publisher · View at Google Scholar · View at PubMed
  95. E. M. Goetz, B. Shankar, Y. Zou et al., “ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability,” Oncogene, vol. 30, no. 35, pp. 3745–3754, 2011. View at Publisher · View at Google Scholar · View at PubMed
  96. R. Medeiros, R. D. Prediger, G. F. Passos et al., “Connecting TNF-α signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid β protein,” Journal of Neuroscience, vol. 27, no. 20, pp. 5394–5404, 2007. View at Publisher · View at Google Scholar · View at PubMed
  97. J. Nandi, B. Saud, J. M. Zinkievich, Z. J. Yang, and R. A. Levine, “TNF-α modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis,” Molecular and Cellular Biochemistry, vol. 336, no. 1-2, pp. 17–24, 2009. View at Publisher · View at Google Scholar · View at PubMed
  98. M. Natarajan, C. F. Gibbons, S. Mohan, S. Moore, and M. A. Kadhim, “Oxidative stress signalling: a potential mediator of tumour necrosis factor α-induced genomic instability in primary vascular endothelial cells,” British Journal of Radiology, vol. 80, supplement 1, pp. S13–S22, 2007. View at Publisher · View at Google Scholar · View at PubMed
  99. B. Yan, Y. Peng, and C. Y. Li, “Molecular analysis of genetic instability caused by chronic inflammation,” Methods in Molecular Biology, vol. 512, pp. 15–28, 2009. View at Publisher · View at Google Scholar
  100. I. M. Adcock, L. Tsaprouni, P. Bhavsar, and K. Ito, “Epigenetic regulation of airway inflammation,” Current Opinion in Immunology, vol. 19, no. 6, pp. 694–700, 2007. View at Publisher · View at Google Scholar · View at PubMed
  101. F. Armenante, M. Merola, A. Furia, and M. Palmieri, “Repression of the IL-6 gene is associated with hypermethylation,” Biochemical and Biophysical Research Communications, vol. 258, no. 3, pp. 644–647, 1999. View at Publisher · View at Google Scholar · View at PubMed
  102. S. Garaud, C. Le Dantec, S. Jousse-Joulin et al., “IL-6 Modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation,” Journal of Immunology, vol. 182, no. 9, pp. 5623–5632, 2009. View at Publisher · View at Google Scholar · View at PubMed
  103. H. Isomoto, J. L. Mott, S. Kobayashi et al., “Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing,” Gastroenterology, vol. 132, no. 1, pp. 384–396, 2007. View at Publisher · View at Google Scholar · View at PubMed
  104. R. Thaler, M. Agsten, S. Spitzer et al., “Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation,” Journal of Biological Chemistry, vol. 286, no. 7, pp. 5578–5588, 2010. View at Publisher · View at Google Scholar · View at PubMed
  105. K. F. To, M. W. Chan, W. K. Leung et al., “Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line,” British Journal of Cancer, vol. 91, no. 7, pp. 1335–1341, 2004. View at Publisher · View at Google Scholar · View at PubMed
  106. H. H. Niller, H. Wolf, and J. Minarovits, “Epigenetic dysregulation of the host cell genome in Epstein-Barr virus-associated neoplasia,” Seminars in Cancer Biology, vol. 19, no. 3, pp. 158–164, 2009. View at Publisher · View at Google Scholar · View at PubMed
  107. F. Chen, Y. Mo, H. Ding et al., “Frequent epigenetic inactivation of Myocardin in human nasopharyngeal carcinoma,” Head and Neck, vol. 33, no. 1, pp. 54–59, 2011. View at Publisher · View at Google Scholar · View at PubMed
  108. C. Du, T. Huang, D. Sun et al., “CDH4 as a novel putative tumor suppressor gene epigenetically silenced by promoter hypermethylation in nasopharyngeal carcinoma,” Cancer Letters, vol. 309, no. 1, pp. 54–61, 2011. View at Publisher · View at Google Scholar · View at PubMed
  109. S. Wang, X. Xiao, X. Zhou et al., “TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma,” BMC Cancer, vol. 10, article 617, 2010. View at Publisher · View at Google Scholar · View at PubMed
  110. Z. Zhang, D. Sun, N. Van Do, A. Tang, L. Hu, and G. Huang, “Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma,” International Journal of Cancer, vol. 120, no. 1, pp. 32–38, 2007. View at Publisher · View at Google Scholar · View at PubMed
  111. D. Rossetto, A. W. Truman, S. J. Kron, and J. Cote, “Epigenetic modifications in double-strand break DNA damage signaling and repair,” Clinical Cancer Research, vol. 16, no. 18, pp. 4543–4552, 2010. View at Publisher · View at Google Scholar · View at PubMed
  112. T. Sawa and H. Ohshima, “Nitrative DNA damage in inflammation and its possible role in carcinogenesis,” Nitric Oxide, vol. 14, no. 2, pp. 91–100, 2006. View at Publisher · View at Google Scholar · View at PubMed
  113. F. Colotta, P. Allavena, A. Sica, C. Garlanda, and A. Mantovani, “Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability,” Carcinogenesis, vol. 30, no. 7, pp. 1073–1081, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  114. G. P. Pfeifer and A. Besaratinia, “Mutational spectra of human cancer,” Human Genetics, vol. 125, no. 5-6, pp. 493–506, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus