Natural Killer Cell Regulation by MicroRNAs in Health and Disease

Table 2

Selected up- or down-regulated miRNAs during cytokine activation of NK cells. miRNAs were selected based on the following criteria: top three fold change within the top 12 expressed miRNAs [35], significant miRNAs consistently changed by the listed stimulation [36], and top three fold change [37].

	Wang, 2012 (human) [35]	Liu, 2012 (human) [36]	Fehniger, 2010 (mouse) [37]
Stimulation	IFN-α	IL-2, IL-15, or IL-21	IL-15
Duration	12 or 24 hours	36 hours	24 hours
Up-regulated	hsa-let-7b	hsa-miR-155	mmu-miR-188-5p
		hsa-miR-15a	mmu-miR-339-5p
			mmu-miR-19a
Down-regulated	hsa-miR-378	hsa-miR-1246	mmu-miR-223
	hsa-miR-103	hsa-miR-331-3p	mmu-miR-26b
	hsa-miR-30e		mmu-miR-181a