Table 3: Summary of global miRNA-deficient or over-expression (Eri ) NK cells. *In particular, at latest stages of NK cell maturation. **In response to activating (ITAM) receptor-mediated stimulation.

Bezman et al. [38]Sullivan et al. [39]Thomas et al. [40]

Cre Model ER-Cre hCD2-Cre Global Knockout
GeneDicerfl/fl/DGCR8fl/flDicerfl/flEri1−/−
Effect on miRNAs
Proliferation
# NK Cells * * *
Survival
IFN-γ production ** **
Degranulation (CD107a)
Receptor Repertoire
Alterations
NKG2DNone Observed Multiple, especially Ly49H/D
MCMV Response IFN-γ production
Ly49H+ NK Cells
↑IFN-γ Production IFN-γ production
Ly49H+ NK Cells
In vitro CytotoxicityNot reportedNot reported