Table 3: Summary of global miRNA-deficient or over-expression (Eri) NK cells. *In particular, at latest stages of NK cell maturation. **In response to activating (ITAM) receptor-mediated stimulation.

Bezman et al. [38] Sullivan et al. [39] Thomas et al. [40] Cre Model ER-Cre hCD2-Cre Global Knockout Gene Dicerfl/fl/DGCR8fl/fl Dicerfl/fl Eri1−/− Effect on miRNAs ↓ ↓ ↑ Proliferation ↓ ↓ ↓ # NK Cells ↓ * ↓ * ↓ * Survival ↓ ↓ ↔ IFN-γ production ↓ ** ↑ ↓ ** Degranulation (CD107a) ↓ ↑ ↔ Receptor Repertoire Alterations ↓NKG2D None Observed Multiple, especially ↓Ly49H/D MCMV Response ↔ IFN-γ production ↓Ly49H+ NK Cells ↑IFN-γ Production ↔ IFN-γ production ↓Ly49H+ NK Cells In vitro Cytotoxicity Not reported Not reported ↔