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Journal of Biomedicine and Biotechnology
Volume 2012 (2012), Article ID 648170, 6 pages
Triiodothyronine Represses MUC5AC Expression by Antagonizing Sp1 Binding to Its Promoter in Human Bronchial Epithelial HBE16 Cells
1Division of Respiratory Medicine, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
2Far Eastern Scientific Center of Physiology and Pathology of Respiration, Siberian Branch, Russian Academy of Medical Sciences, 675000 Blagoveschensk, Russia
Received 27 August 2011; Revised 9 November 2011; Accepted 9 November 2011
Academic Editor: Anton M. Jetten
Copyright © 2012 Xiaolong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- H. W. J. Young, C. X. Sun, C. M. Evans, B. F. Dickey, and M. R. Blackburn, “A3 adenosine receptor signaling contributes to airway mucin secretion after allergen challenge,” American Journal of Respiratory Cell and Molecular Biology, vol. 35, no. 5, pp. 549–558, 2006.
- M. O. Henke, G. John, M. Germann, H. Lindemann, and B. K. Rubin, “MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation,” American Journal of Respiratory and Critical Care Medicine, vol. 175, no. 8, pp. 816–821, 2007.
- K. Wang, Y. L. Feng, F. Q. Wen et al., “Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease,” Chinese Medical Journal, vol. 120, no. 12, pp. 1051–1057, 2007.
- M. C. Rose and J. A. Voynow, “Respiratory tract mucin genes and mucin glycoproteins in health and disease,” Physiological Reviews, vol. 86, no. 1, pp. 245–278, 2006.
- M. R. Knowles and R. C. Boucher, “Mucus clearance as a primary innate defense mechanism for mammalian airways,” Journal of Clinical Investigation, vol. 109, no. 5, pp. 571–577, 2002.
- M. C. Rose, T. J. Nickola, and J. A. Voynow, “Airway mucus obstruction: mucin glycoproteins, MUC gene regulation and goblet cell hyperplasia,” American Journal of Respiratory Cell and Molecular Biology, vol. 25, no. 5, pp. 533–537, 2001.
- J. H. Vernooy, M. Küçükaycan, J. A. Jacobs et al., “Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum,” American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 9, pp. 1218–1224, 2002.
- J. H. Yoon, T. Gray, K. Guzman, J. S. Koo, and P. Nettesheim, “Regulation of the secretory phenotype of human airway epithelium by retinoic acid, triiodothyronine, and extracellular matrix,” American Journal of Respiratory Cell and Molecular Biology, vol. 16, no. 6, pp. 724–731, 1997.
- T. Gray, P. Nettesheim, C. Basbaum, and J. S. Koo, “Regulation of mucin gene expression in human tracheobronchial epithelial cells by thyroid hormone,” Biochemical Journal, vol. 353, no. 3, pp. 727–734, 2001.
- T. Gray, J. S. Koo, and P. Nettesheim, “Regulation of mucous differentiation and mucin gene expression in the tracheobronchial epithelium,” Toxicology, vol. 160, no. 1–3, pp. 35–46, 2001.
- J. S. Koo, J. H. Yoon, T. Gray, D. Norford, A. M. Jetten, and P. Nettesheim, “Restoration of the mucous phenotype by retinoic acid in retinoid-deficient human bronchial cell cultures: changes in mucin gene expression,” American Journal of Respiratory Cell and Molecular Biology, vol. 20, no. 1, pp. 43–52, 1999.
- P. J. Tai, Y. H. Huang, C. H. Shih et al., “Direct regulation of androgen receptor-associated protein 70 by thyroid hormone and its receptors,” Endocrinology, vol. 148, no. 7, pp. 3485–3495, 2007.
- M. Beato, “Transcriptional control by nuclear receptors,” FASEB Journal, vol. 5, no. 7, pp. 2044–2051, 1991.
- G. Graupner, K. N. Wills, M. Tzukerman, X. Zhang, and M. Pfahl, “Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity,” Nature, vol. 340, no. 6235, pp. 653–656, 1989.
- M. Tomic, C. K. Jiang, H. S. Epstein, I. M. Freedberg, H. H. Samuels, and M. Blumenberg, “Nuclear receptors for retinoic acid and thyroid hormone regulate transcription of keratin genes,” Cell regulation, vol. 1, no. 12, pp. 965–973, 1990.
- S. K. Moon, J. H. Yoon, H. N. Kim, D. J. Lim, and M. H. Chung, “Effects of retinoic acid, triiodothyronine and hydrocortisone on mucin and lysozyme expression in cultured human middle ear epithelial cells,” Acta Oto-Laryngologica, vol. 120, no. 8, pp. 944–949, 2000.
- C. A. Hewson, M. R. Edbrooke, and S. L. Johnston, “PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-α, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms,” Journal of Molecular Biology, vol. 344, no. 3, pp. 683–695, 2004.
- J.M. Weitzel, “To bind or not to bind - how to down-regulate target genes by liganded thyroid hormone receptor?” Thyroid Research, vol. 11, no. 1, p. 4, 2008.
- M. A. Lazar, “Thyroid hormone action: a binding contract,” Journal of Clinical Investigation, vol. 112, no. 4, pp. 497–499, 2003.