Analyzing Gene Expression Profile in K562 Cells Exposed to Sodium Valproate Using Microarray Combined with the Connectivity Map Database

Table 2

Differentially expressed genes involved in apoptosis detected by significant enrichment analysis of GO terms using the R language software package.

Genes	GenBank accession	Fold change	Gene description
PDCD7	NM_005707	−2.20	Programmed cell death 7
RRAGA	NM_006570	2.03	Ras-related GTP binding A
DAPK3	NM_001348	2.04	Death-associated protein kinase 3
PUF60	NM_014281	−2.00	Poly-U binding splicing factor 60kda isoform c
FOXO3	NM_001455	2.16	Forkhead box O3A
ARHGEF18	NM_015318	2.20	Rho/Rac guanine nucleotide exchange factor 18
BBC3	NM_014417	−2.18	BCL2 binding component 3 isoform 1
GSN	NM_198252	5.02	Gelsolin isoform c
LGALS1	NM_033101	2.58	Galectin-1
NFKB1	NM_003998	−3.33	Nuclear factor kappa-B, subunit 1 isoform 1
SH3GLB1	NM_016009	2.82	SH3-containing protein SH3GLB1
POLR2G	NM_002696	2.02	DNA directed RNA polymerase II polypeptide G
DDIT4	NM_019058	−2.23	Homo sapiens DNA-damage-inducible transcript 4
STEAP3	NM_182915	−2.52	Dudulin 2 isoform a
DRAM1	NM_018370	2.29	DNA-damage regulated autophagy modulator 1
RNF130	NM_018434	2.07	Ring finger protein 130 precursor
AVEN	NM_020371	−2.62	Cell death regulator Aven
TRIB3	NM_021158	−2.19	Tribbles 3
BAX	NM_138764	2.06	BCL2-associated X protein isoform beta
BID	NM_197966	−2.76	BH3 interacting domain death agonist isoform 1
PERP	NM_022121	9.42	PERP, TP53 apoptosis effector
SPTAN1	NM_003127	2.63	Spectrin, alpha, nonerythrocytic 1
BUB1B	NM_001211	−2.20	Budding uninhibited by benzimidazoles 1 beta
VDAC1	NM_003374	−2.37	Voltage-dependent anion channel 1
BCL2L12	NM_138639	2.19	BCL2-like 12 isoform 1
CUL1	NM_003592	−2.08	Cullin 1
YARS	NM_001040436	−2.30	Tyrosyl-TRNA synthetase
TNFSF9	NM_003811	2.38	Tumor necrosis factor (ligand) superfamily
IER3	NM_003897	2.17	Immediate early response 3
ARHGEF2	NM_004723	−2.10	Rho/Rac guanine nucleotide exchange factor 2
TP53INP1	NM_033285	3.03	Tumor protein p53 inducible nuclear protein 1
ITM2B	NM_021999	2.32	Integral membrane protein 2B
LITAF	NM_004862	2.25	Lipopolysaccharide-induced TNF-alpha factor
ESPL1	NM_012291	−2.11	Separase

−: indicate downregulation.