Table 3: Top CMAP hits correlated with gene expression signature induced by VPA.

RankCMAP drugPMean scoreEnrichmentSpecificityPercent nonnullFunction

1Vorinostat0.000000.9180.9740.0201100HDACi
2Trichostatin A0.000000.8170.9570.000096HDACi
3Wortmannin0.000000.3350.6950.006577PI3K inhibitor
4Ly-2940020.000000.3250.5640.020165PI3K inhibitor
5VPA0.000000.3700.5160.000061Anti-epileptic; HDACi; Mood stabilizer
6Raloxifene0.000020.3020.7890.000085SERM
7Trifluoperazine0.000020.3030.5940.115468Antipsychotic
8Scriptaid0.000040.7280.9680.0185100HDACi
9Rifabutin0.000040.8020.9670.0052100Antimycobacterial agent
10Thioridazine0.000080.2600.4860.283165Antipsychotic

The connectivity score, similarity measurement of the gene expression profile between the query signature and that of a CMAP instance, ranges from −1 to 1. Only drugs with positive connectivity scores, which induce the expression of the query signature, are listed. HDACi: histone deacetylase inhibitor. SERM: selective estrogen receptor modulator. VPA: valproic acid.